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The NICHD Microscopy and Imaging Core (MIC) is designed as a multi-user research facility providing training and instrumentation for high resolution microscopy and image processing. The core is located on the ground floor of building 35A. It is equipped with several point scanning confocal microscopes (Zeiss LSM 510 meta inverted, Zeiss LSM 510 meta upright 2-photon, Zeiss 780LSM inverted, Nikon Spinning Disk/Storm/TIRF), a sub-resolution imaging platform (PALM instrument), and three wide-field fluorescence microscopes (Olympus BX61 upright, Olympus Wide Field Inverted, Olympus and Zeiss Lumar stereo-microscopes), together with a Jeol 1400 Transmission Electron Microscope.
The mission of the Core is to provide training, support and instruments for all investigators in PNRC who require high-resolution microscopy in their research. In addition, the Core is involved in technology development focused on improving, automating, and providing enhanced access to advanced imaging technologies, including:
- Confocal Microscopy
- Time-lapse imaging
- Fluorescence methodologies (FRAP, FRET, uncaging, photo-activation)
- Sub-resolution microscopy (TIRF, PALM)
- Multi--photon imaging
- Image processing
- Remote users: The MIC offers full fledged Tissue Culture Facilities.
- Tissue processing: Cryostat, sliding microtome (floating sections) and two vibratomes available.
- Transcardial Perfusion: The MIC prep space houses a gravity-driven system, capable of 3 preparations. Training or the service is available.
- Immunofluorescence Staining: Equipment and space set aside for fluorescence-based staining protocols.
- Zeiss Lumar fluorescence stereo microscope.
- Zeiss Axiovert 200 with AxioCam Color Camera (for imaging color reactions).
- Sub-resolution (PALM) instrument.
- Jeol JEM 1400 electron microscope!
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