The Section on Neuronal Connectivity, headed by Chi-Hon Lee, investigates the development and function of color-vision circuits in Drosophila. His group found that TGF-beta/Activin signaling plays a key role in coordinating mutual synaptogenesis between R7 photoreceptors and their target neurons Dm8. His group is also developing genetic tools to dissect color-vision circuits. By selectively inactivating or restoring the synaptic activity of various types of neurons, his group recently demonstrated that spectral preference to UV and green light is mediated by two distinct types of second-order interneurons.
- Website: http://science.nichd.nih.gov/confluence/display/snc/Home
- Annual Report: http://annualreport.nichd.nih.gov/snc.html