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Eunice Kennedy Shriver National Institute of Child Health and Human Development - Program in Cellular Regulation and Metabolism
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Chi-Hon Lee

The Section on Neuronal Connectivity, headed by Chi-Hon Lee, investigates the development and function of color-vision circuits in Drosophila. His group found that TGF-beta/Activin signaling plays a key role in coordinating mutual synaptogenesis between R7 photoreceptors and their target neurons Dm8. His group is also developing genetic tools to dissect color-vision circuits. By selectively inactivating or restoring the synaptic activity of various types of neurons, his group recently demonstrated that spectral preference to UV and green light is mediated by two distinct types of second-order interneurons.


The Genetic Analysis of Functional Connectomics in Drosophila (submitted)


Wardill, T.J., List, O., Li, X., Dongre, S., McCulloch, M., Ting, C.-Y., O’Kane, C. J., Tang, S., Lee, C.-H., Hardie, R. C., Juusola, M. (2012) Multiple Spectral Inputs Contribute to Motion Discrimination in the Drosophila Visual System. Science, 336, 925-931.

Brody, T., Yavatkar, A.S., Kuzin, A., Kundu, M., Tyson, L.J., Ross. J., Lin, T.-Y., Lee, C.-H., Awasaki, T., Lee, T., Odenwald. W.F. (2012) Use of a Drosophila genome-wide conserved sequence database to identify functionally related cis-regulatory enhancers. Dev Dyn, 241, 169-189. 

Takemura, S., Karuppudurai,  T., Ting, C.-Y., Lu,  Z., Lee, C.-H.,# Meinertzhagen, I.A.# (2011) Cholinergic circuits integrate neighboring visual signals in a Drosophila motion detection pathway. Current Biology, 21, 2077-2084. 

Melnattur, K.V. and Lee, C.-H. (2011) Visual Circuit Assembly in Drosophila. Dev Neurobiol, 36, 1286-96 

Ting, C.-Y., Gu, S., Guttikonda, S., Lin, T.-Y., White, B.H., Lee, C.-H. (2011) Focusing transgene expression in Drosophila by coupling Gal4 with a novel split-LexA expression system. Genetics,188, 229-233 

Lee, C.-H. (2010) The split view of motion. Nature, 486, 178-179.

Hsu, S.N., Yonekura, S, Ting, C.-Y., Robertson, H.M., Iwai, Y., Uemura, T., Lee, C.-H., Chiba, A. (2009) Conserved alternative splicing and expression patterns of arthropod N-cadherin. PLoS Genet. 5, e1000441.

Meinertzhagen, I.A., Takemura, S.-y., Lu, Z., Huang, S., Gao, S., Ting, C.-Y., Lee, C.-H. (2009) From form to function: the ways to know a neuron. Journal of Neurogenetics, 29, 828-41.

Gao, S., Takemura, S.-y., Ting, C.-Y., Huang, S., Lu, Z., Luan, H., Rister, J., Thum, A. S., Yang, M., Hong, S.-T., Wang, J.W., Odenwald, W.F., White, B.H., Meinertzhagen, I.A., Lee, C.-H. (2008) The Neural Substrate of Spectral Preference in Drosophila. Neuron, 60, 328-42.

Root, C.M., Masuyama, K., Green, D.S., Enell, L.E., Nassel, D.R., Lee, C.-H., Wang, J.W. (2008) A presynaptic gain control mechanism fine-tunes olfactory behavior. Neuron 59, 311-21.

Ting, C.-Y., Herman, T., Yonekura S., Gao, S., Wang, J., Serpe, M., O'Connor, M.B., Zipursky, S.L., Lee, C.-H. (2007) Tiling of R7 axons in the Drosophila visual system is mediated both by transduction of an Activin signal to the nucleus and by mutual repulsion. Neuron 56, 793-806.

Rister, J., Pauls, D., Schnell, B., Ting, C.-Y., Lee, C.-H., Sinakevitch, I., Morante, J., Strausfeld, N.J., Ito, K., Heisenberg, M. (2007) Dissection of the Peripheral Motion Channel in the Visual System of Drosophila melanogaster. Neuron 56, 155-70.

Yonekura S., Lei Xu, Ting C.-Y., Lee C.-H. (2007) Adhesive but not signaling activity of Drosophila N-cadherin is essential for photoreceptor target selection. Dev. Biol. 304, 759-70.

Ting C.-Y., Lee C.-H. (2007)Visual circuit development. Curr Opin Neurobiol. 17, 65-72.

Yonekura S., Ting C.-Y., Neves G., Hung K., Hsu S., Chiba A., Chess A., Lee C.-H. (2006) The variable transmembrane domain of Drosophila N-cadherin regulates adhesive activity. Mol Cell Biol. 20, 6598-6608.

Pramatarova A, Ochalski PG, Lee C.-H., Howell B.W. (2006) Mouse disabled 1 regulates the nuclear position of neurons in a Drosophila eye model. Mol Cell Biol. 26, 1510-7.

Ting C.-Y., Yonekura S., Chung, P., Hsu, S., Robertson, H.M., Chiba, A., Lee, C.-H., (2005) Drosophila N-cadherin functions in the first stage of the two-stage layer-selection process of R7 photoreceptor afferents. Development 132, 953-963.

Lee, R. C., Clandinin, T.  R., Lee, C.-H., Chen, P.L., Meinertzhagen, I. A., Zipursky, S. L., (2003) The protocadherin Flamingo is required for axon target selection in the Drosophila visual system. Nat. Neurosci. 6, 557-63.

Clandinin, T. R., Lee, C.-H.*, Herman, T., Lee, R. C., Yang, A. Y., Ovasapyan, S., and Zipursky, S. L., (2001) Drosophila LAR regulates R1-R6 and R7 target specificity in the visual system. Neuron 32,237-248.

Lee, C.-H., Herman, T., Clandinin, T.R., Lee, R., Zipursky, S.L., (2001) N-cadherin regulates target specificity in the Drosophila visual system. Neuron 30, 437-50.

Garrity, P.A., Lee, C.-H.*, Salecker, I., Robertson, H.C., Desai, C.J., Zinn, K. and Zipursky, S.L. (1999) Retinal axon target selection in Drosophila is regulated by a receptor protein tyrosine phosphatase. Neuron 22, 707-717.

Lee, C.-H., Cowburn, D., Kuriyan, J. (1998) Peptide recognition mechanisms of eukaryotic signaling modules. Methods Mol. Biol. 84, 3-31.

Zhang, Z., Lee, C.-H.*, Mandiyan, V., Borg, J.P., Margolis, B., Schlessinger, J., Kuriyan, J., (1997) Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain. EMBO J. 16, 6141-6150.

Moarefi, I., LaFeyre-Bernt., M., Sicheri, F., Huse, M., Lee, C.-H., Kuriyan, J., Miller, W.T. (1997) Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement. Nature 385, 650-653.

Lee, C.-H., Saksela, K., Mirza, U., Chait, B. and Kuriyan, J. (1996) Crystal structure of the conserved core of HIV-1 Nef complexed with a Src-family SH3 domain. Cell 85, 931-942.

Lee, C.-H., Leung, B., Lemmon, M.A., Zheng, J., Cowburn, D., Kuriyan, J. and Saksela, K. (1995) A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein. EMBO J. 14, 5006-5015.

Lee, C.-H., Kominos, D., Jacques, S., Margolis, B., Schlessinger, J., Shoelson, S.E. and Kuriyan, J. (1994) Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase. Structure 15, 423-438.

Lee, C.-H., Lee, E.-C., Tai, S.-T., Kung, H.-J., Liu, Y.-C. and Hwang, J. (1993) A recombinant protein composed of Epidermal growth factor and Pseudomonas Exotoxin A with a deletion of toxin binding domain specifically kills EGF-receptor bearing cells. Protein Engineering 6, 433-440.

Skolnik, E.Y., Batzer, A.G., Li, N., Lee, C.-H., Lowenstein, E., Mohammedi, M., Margolis, B. and Schlessinger, J. (1993) The function of GRB2 in linking the insulin receptor to Ras signaling pathways. Science 260, 1953-1955.

Skolnik, E.Y., Lee, C.-H., Batzer, A.G., Zhou, M., Daly, R., Backer, J., White, M.F., Jr., and Schlessinger, J. (1993) The SH2/SH3 domain containing protein GRB2 implicated in RAS signaling interacts with two insulin induced substrates. EMBO J. 12, 1929-1936.

Lee, C.-H., Li, W., Nishimura, R., Zhou, M., Batzer, A.G., Myers, M.G., White, M.F., Jr., Schlessinger, J. and Skolnik, E.Y. (1993) Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells. Proc. Natl. Acad. Sci. USA 90, 11713-11717.

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