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Eunice Kennedy Shriver National Institute of Child Health and Human Development - Program in Cellular Regulation and Metabolism
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Thomas Dever

The Section on Protein Biosynthesis, headed by Thomas Dever, is characterizing the structure and function of several translation initiation factors and the molecular principles of kinase-substrate recognition by the stress-responsive eIF2a kinases.

The group recently reported that rapid evolution of the kinase domain of the eIF2a kinase PKR alters the sensitivity of the kinase to poxvirus inhibitors, identified functionally important contacts between the GTPase translation factor eIF5B and the body of the small (40S) ribosomal subunit, and demonstrated that the hypusine-containing protein eIF5A promotes translation elongation.

Publications

  • Dever TE, Green R. The elongation, termination, and recycling phases of translation in eukaryotes. Cold Spring Harb Perspect Biol. 2012 Jul 1;4(7):a013706. doi: 10.1101/cshperspect.a013706. PubMed PMID: 22751155.
  • Dever TE. Molecular biology. A new start for protein synthesis. Science. 2012 Jun 29;336(6089):1645-6. PubMed PMID: 22745408.
  • Zhang M, Mishra S, Sakthivel R, Rojas M, Ranjan R, Sullivan WJ Jr, Fontoura BM, Ménard R, Dever TE, Nussenzweig V. PK4, a eukaryotic initiation factor 2α(eIF2α) kinase, is essential for the development of the erythrocytic cycle of Plasmodium. Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3956-61. Epub 2012 Feb 21. PubMed PMID: 22355110; PubMed Central PMCID: PMC3309761.
  • Shin BS, Kim JR, Walker SE, Dong J, Lorsch JR, Dever TE. Initiation factor eIF2γ promotes eIF2-GTP-Met-tRNAi(Met) ternary complex binding to the 40S ribosome. Nat Struct Mol Biol. 2011 Oct 16;18(11):1227-34. doi: 10.1038/nsmb.2133. PubMed PMID: 22002225; PubMed Central PMCID: PMC3210414.
  • Rothenburg S, Chinchar VG, Dever TE. Characterization of a ranavirus inhibitor of the antiviral protein kinase PKR. BMC Microbiol. 2011 Mar 18;11:56. PubMed PMID: 21418572; PubMed Central PMCID: PMC3068933.
  • Dey M, Velyvis A, Li JJ, Chiu E, Chiovitti D, Kay LE, Sicheri F, Dever TE. Requirement for kinase-induced conformational change in eukaryotic initiation factor 2alpha (eIF2alpha) restricts phosphorylation of Ser51. Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4316-21. Epub 2011 Feb 28. PubMed PMID: 21368187; PubMed Central PMCID: PMC3060252.
  • Shin BS, Acker MG, Kim JR, Maher KN, Arefin SM, Lorsch JR, Dever TE. Structural integrity of (alpha)-helix H12 in translation initiation factor eIF5B is critical for 80S complex stability. RNA. 2011 Apr;17(4):687-96. Epub 2011 Feb 18. PubMed PMID: 21335519; PubMed Central PMCID: PMC3062179.
  • Lorsch JR, Dever TE. Molecular view of 43 S complex formation and start site selection in eukaryotic translation initiation. J Biol Chem. 2010 Jul 9;285(28):21203-7. Epub 2010 May 5. Review. PubMed PMID: 20444698; PubMed Central PMCID: PMC2898419.
  • Dev K, Santangelo TJ, Rothenburg S, Neculai D, Dey M, Sicheri F, Dever TE, Reeve JN, Hinnebusch AG. Archaeal aIF2B interacts with eukaryotic translation initiation factors eIF2alpha and eIF2Balpha: Implications for aIF2B function and eIF2B regulation. J Mol Biol. 2009 Sep 25;392(3):701-22. Epub 2009 Jul 17. PubMed PMID: 19616556; PubMed Central PMCID: PMC2937263.
  • Saini P, Eyler DE, Green R, Dever TE. Hypusine-containing protein eIF5A promotes translation elongation. Nature. 2009 May 7;459(7243):118-21. PubMed PMID: 19424157; PubMed Central PMCID: PMC3140696.
  • Gárriz A, Qiu H, Dey M, Seo EJ, Dever TE, Hinnebusch AG. A network of hydrophobic residues impeding helix alphaC rotation maintains latency of kinase Gcn2, which phosphorylates the alpha subunit of translation initiation factor 2. Mol Cell Biol. 2009 Mar;29(6):1592-607. Epub 2008 Dec 29. PubMed PMID: 19114556; PubMed Central PMCID: PMC2648240.
  • Rothenburg S, Seo EJ, Gibbs JS, Dever TE, Dittmar K. Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors. Nat Struct Mol Biol. 2009 Jan;16(1):63-70. Epub 2008 Nov 30. PubMed PMID: 19043413; PubMed Central PMCID: PMC3142916.
  • Shin BS, Kim JR, Acker MG, Maher KN, Lorsch JR, Dever TE. rRNA suppressor of a eukaryotic translation initiation factor 5B/initiation factor 2 mutant reveals a binding site for translational GTPases on the small ribosomal subunit. Mol Cell Biol. 2009 Feb;29(3):808-21. Epub 2008 Nov 24. PubMed PMID: 19029250; PubMed Central PMCID: PMC2630678.
  • Acker MG, Shin BS, Nanda JS, Saini AK, Dever TE, Lorsch JR. Kinetic analysis of late steps of eukaryotic translation initiation. J Mol Biol. 2009 Jan 16;385(2):491-506. Epub 2008 Oct 19. PubMed PMID: 18976658; PubMed Central PMCID: PMC2654283.
  • Seo EJ, Liu F, Kawagishi-Kobayashi M, Ung TL, Cao C, Dar AC, Sicheri F, Dever TE. Protein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein. Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):16894-9. Epub 2008 Oct 29. PubMed PMID: 18971339; PubMed Central PMCID: PMC2579349.
  • Alone PV, Cao C, Dever TE. Translation initiation factor 2gamma mutant alters start codon selection independent of Met-tRNA binding. Mol Cell Biol. 2008 Nov;28(22):6877-88. Epub 2008 Sep 15. PubMed PMID: 18794367; PubMed Central PMCID: PMC2573310.
  • Costa-Mattioli M, Bidinosti M, Dever TE. Getting the message in protein synthesis. Keystone Symposium on Translational Regulatory Mechanisms. EMBO Rep. 2008 Oct;9(10):954-9. Epub 2008 Aug 29. Review. PubMed PMID: 18758437; PubMed Central PMCID: PMC2572128.
  • Rothenburg S, Deigendesch N, Dey M, Dever TE, Tazi L. Double-stranded RNA-activated protein kinase PKR of fishes and amphibians: varying the number of double-stranded RNA binding domains and lineage-specific duplications. BMC Biol. 2008 Mar 3;6:12. PubMed PMID: 18312693; PubMed Central PMCID: PMC2291453.
  • Lee KP, Dey M, Neculai D, Cao C, Dever TE, Sicheri F. Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing. Cell. 2008 Jan 11;132(1):89-100. PubMed PMID: 18191223; PubMed Central PMCID: PMC2276645.
  • Shin BS, Dever TE. Molecular genetic structure-function analysis of translation initiation factor eIF5B. Methods Enzymol. 2007;429:185-201. PubMed PMID: 17913624.
  • Moraes MC, Jesus TC, Hashimoto NN, Dey M, Schwartz KJ, Alves VS, Avila CC, Bangs JD, Dever TE, Schenkman S, Castilho BA. Novel membrane-bound eIF2alpha kinase in the flagellar pocket of Trypanosoma brucei. Eukaryot Cell. 2007 Nov;6(11):1979-91. Epub 2007 Sep 14. PubMed PMID: 17873083; PubMed Central PMCID: PMC2168417.
  • Fringer JM, Acker MG, Fekete CA, Lorsch JR, Dever TE. Coupled release of eukaryotic translation initiation factors 5B and 1A from 80S ribosomes following subunit joining. Mol Cell Biol. 2007 Mar;27(6):2384-97. Epub 2007 Jan 22. PubMed PMID: 17242201; PubMed Central PMCID: PMC1820483.
  • Dey M, Cao C, Sicheri F, Dever TE. Conserved intermolecular salt bridge required for activation of protein kinases PKR, GCN2, and PERK. J Biol Chem. 2007 Mar 2;282(9):6653-60. Epub 2007 Jan 3. PubMed PMID: 17202131.
  • Shin BS, Acker MG, Maag D, Kim JR, Lorsch JR, Dever TE. Intragenic suppressor mutations restore GTPase and translation functions of a eukaryotic initiation factor 5B switch II mutant. Mol Cell Biol. 2007 Mar;27(5):1677-85. Epub 2006 Dec 22. PubMed PMID: 17189426; PubMed Central PMCID: PMC1820465.
  • Alone PV, Dever TE. Direct binding of translation initiation factor eIF2gamma-G domain to its GTPase-activating and GDP-GTP exchange factors eIF5 and eIF2B epsilon. J Biol Chem. 2006 May 5;281(18):12636-44. Epub 2006 Mar 7. PubMed PMID: 16522633.
  • Acker MG, Shin BS, Dever TE, Lorsch JR. Interaction between eukaryotic initiation factors 1A and 5B is required for efficient ribosomal subunit joining. J Biol Chem. 2006 Mar 31;281(13):8469-75. Epub 2006 Feb 3. PubMed PMID: 16461768.
  • Dey M, Cao C, Dar AC, Tamura T, Ozato K, Sicheri F, Dever TE. Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition. Cell. 2005 Sep 23;122(6):901-13. PubMed PMID: 16179259.
  • Dar AC, Dever TE, Sicheri F. Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR. Cell. 2005 Sep 23;122(6):887-900. PubMed PMID: 16179258.
  • Dever TE, Hinnebusch AG. GCN2 whets the appetite for amino acids. Mol Cell. 2005 Apr 15;18(2):141-2. PubMed PMID: 15837415.
  • Dey M, Trieselmann B, Locke EG, Lu J, Cao C, Dar AC, Krishnamoorthy T, Dong J, Sicheri F, Dever TE. PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2alpha. Mol Cell Biol. 2005 Apr;25(8):3063-75. PubMed PMID: 15798194; PubMed Central PMCID: PMC1069625.
  • Klann E, Dever TE. Biochemical mechanisms for translational regulation in synaptic plasticity. Nat Rev Neurosci. 2004 Dec;5(12):931-42. Review. PubMed PMID: 15550948.
  • Kazemi S, Papadopoulou S, Li S, Su Q, Wang S, Yoshimura A, Matlashewski G, Dever TE, Koromilas AE. Control of alpha subunit of eukaryotic translation initiation factor 2 (eIF2 alpha) phosphorylation by the human papillomavirus type 18 E6 oncoprotein: implications for eIF2 alpha-dependent gene expression and cell death. Mol Cell Biol. 2004 Apr;24(8):3415-29. PubMed PMID: 15060162; PubMed Central PMCID: PMC381675.
  • Clark MC, Dever TE, Dever JJ, Xu P, Rehder V, Sosa MA, Baro DJ. Arthropod 5-HT2 receptors: a neurohormonal receptor in decapod crustaceans that displays agonist independent activity resulting from an evolutionary alteration to the DRY motif. J Neurosci. 2004 Mar 31;24(13):3421-35. Erratum in: J Neurosci. 2004 May 5;24(18):4489. PubMed PMID: 15056722.
  • Roll-Mecak A, Alone P, Cao C, Dever TE, Burley SK. X-ray structure of translation initiation factor eIF2gamma: implications for tRNA and eIF2alpha binding. J Biol Chem. 2004 Mar 12;279(11):10634-42. Epub 2003 Dec 19. PubMed PMID: 14688270.
  • Dever TE, Roll-Mecak A, Choi SK, Lee JH, Cao C, Shin BS, Burley SK. Universal translation initiation factor IF2/eIF5B. Cold Spring Harb Symp Quant Biol. 2001;66:417-24. Review. PubMed PMID: 12762044.
  • Sonenberg N, Dever TE. Eukaryotic translation initiation factors and regulators. Curr Opin Struct Biol. 2003 Feb;13(1):56-63. Review. PubMed PMID: 12581660.
  • Shin BS, Maag D, Roll-Mecak A, Arefin MS, Burley SK, Lorsch JR, Dever TE. Uncoupling of initiation factor eIF5B/IF2 GTPase and translational activities by mutations that lower ribosome affinity. Cell. 2002 Dec 27;111(7):1015-25. PubMed PMID: 12507428.
  • Lee JH, Pestova TV, Shin BS, Cao C, Choi SK, Dever TE. Initiation factor eIF5B catalyzes second GTP-dependent step in eukaryotic translation initiation. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16689-94. Epub 2002 Dec 6. PubMed PMID: 12471154; PubMed Central PMCID: PMC139205.
  • Ramelot TA, Cort JR, Yee AA, Liu F, Goshe MB, Edwards AM, Smith RD, Arrowsmith CH, Dever TE, Kennedy MA. Myxoma virus immunomodulatory protein M156R is a structural mimic of eukaryotic translation initiation factor eIF2alpha. J Mol Biol. 2002 Oct 4;322(5):943-54. PubMed PMID: 12367520.
  • Zhan K, Vattem KM, Bauer BN, Dever TE, Chen JJ, Wek RC. Phosphorylation of eukaryotic initiation factor 2 by heme-regulated inhibitor kinase-related protein kinases in Schizosaccharomyces pombe is important for fesistance to environmental stresses. Mol Cell Biol. 2002 Oct;22(20):7134-46. PubMed PMID: 12242291; PubMed Central PMCID: PMC139816.
  • Dever TE. Gene-specific regulation by general translation factors. Cell. 2002 Feb 22;108(4):545-56. Review. PubMed PMID: 11909525.
  • Roll-Mecak A, Shin BS, Dever TE, Burley SK. Engaging the ribosome: universal IFs of translation. Trends Biochem Sci. 2001 Dec;26(12):705-9. PubMed PMID: 11738593.
  • Ung TL, Cao C, Lu J, Ozato K, Dever TE. Heterologous dimerization domains functionally substitute for the double-stranded RNA binding domains of the kinase PKR. EMBO J. 2001 Jul 16;20(14):3728-37. PubMed PMID: 11447114; PubMed Central PMCID: PMC125533.
  • Krishnamoorthy T, Pavitt GD, Zhang F, Dever TE, Hinnebusch AG. Tight binding of the phosphorylated alpha subunit of initiation factor 2 (eIF2alpha) to the regulatory subunits of guanine nucleotide exchange factor eIF2B is required for inhibition of translation initiation. Mol Cell Biol. 2001 Aug;21(15):5018-30. PubMed PMID: 11438658; PubMed Central PMCID: PMC87228.
  • Searfoss A, Dever TE, Wickner R. Linking the 3' poly(A) tail to the subunit joining step of translation initiation: relations of Pab1p, eukaryotic translation initiation factor 5b (Fun12p), and Ski2p-Slh1p. Mol Cell Biol. 2001 Aug;21(15):4900-8. PubMed PMID: 11438647; PubMed Central PMCID: PMC87206.
  • Goossens A, Dever TE, Pascual-Ahuir A, Serrano R. The protein kinase Gcn2p mediates sodium toxicity in yeast. J Biol Chem. 2001 Aug 17;276(33):30753-60. Epub 2001 Jun 14. PubMed PMID: 11408481.
  • Zhang F, Romano PR, Nagamura-Inoue T, Tian B, Dever TE, Mathews MB, Ozato K, Hinnebusch AG. Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop. J Biol Chem. 2001 Jul 6;276(27):24946-58. Epub 2001 May 3. PubMed PMID: 11337501.
  • Wong AH, Durbin JE, Li S, Dever TE, Decker T, Koromilas AE. Enhanced antiviral and antiproliferative properties of a STAT1 mutant unable to interact with the protein kinase PKR. J Biol Chem. 2001 Apr 27;276(17):13727-37. Epub 2001 Jan 25. PubMed PMID: 11278865.
  • Roll-Mecak A, Cao C, Dever TE, Burley SK. X-Ray structures of the universal translation initiation factor IF2/eIF5B: conformational changes on GDP and GTP binding. Cell. 2000 Nov 22;103(5):781-92. PubMed PMID: 11114334.
  • Kawagishi-Kobayashi M, Cao C, Lu J, Ozato K, Dever TE. Pseudosubstrate inhibition of protein kinase PKR by swine pox virus C8L gene product. Virology. 2000 Oct 25;276(2):424-34. PubMed PMID: 11040133.
  • Choi SK, Olsen DS, Roll-Mecak A, Martung A, Remo KL, Burley SK, Hinnebusch AG, Dever TE. Physical and functional interaction between the eukaryotic orthologs of prokaryotic translation initiation factors IF1 and IF2. Mol Cell Biol. 2000 Oct;20(19):7183-91. PubMed PMID: 10982835; PubMed Central PMCID:PMC86272.
  • Pestova TV, Lomakin IB, Lee JH, Choi SK, Dever TE, Hellen CU. The joining of ribosomal subunits in eukaryotes requires eIF5B. Nature. 2000 Jan 20;403(6767):332-5. PubMed PMID: 10659855.
  • Lu J, O'Hara EB, Trieselmann BA, Romano PR, Dever TE. The interferon-induced double-stranded RNA-activated protein kinase PKR will phosphorylate serine, threonine, or tyrosine at residue 51 in eukaryotic initiation factor 2alpha. J Biol Chem. 1999 Nov 5;274(45):32198-203. PubMed PMID: 10542257.
  • Dever TE. Translation initiation: adept at adapting. Trends Biochem Sci. 1999
    Oct;24(10):398-403. Review. PubMed PMID: 10500305.
  • Lee JH, Choi SK, Roll-Mecak A, Burley SK, Dever TE. Universal conservation in translation initiation revealed by human and archaeal homologs of bacterial translation initiation factor IF2. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4342-7. PubMed PMID: 10200264; PubMed Central PMCID: PMC16334.
  • Frerichs KU, Smith CB, Brenner M, DeGracia DJ, Krause GS, Marrone L, Dever TE, Hallenbeck JM. Suppression of protein synthesis in brain during hibernation involves inhibition of protein initiation and elongation. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14511-6. PubMed PMID: 9826731; PubMed Central PMCID:PMC24404.
  • Romano PR, Zhang F, Tan SL, Garcia-Barrio MT, Katze MG, Dever TE, Hinnebusch AG. Inhibition of double-stranded RNA-dependent protein kinase PKR by vaccinia virus E3: role of complex formation and the E3 N-terminal domain. Mol Cell Biol. 1998 Dec;18(12):7304-16. PubMed PMID: 9819417; PubMed Central PMCID: PMC109312.
  • Dever TE. Analysis of eIF-2 alpha kinases in yeast. Methods Mol Biol. 1998;77:167-78. Review. PubMed PMID: 9770669.
  • Choi SK, Lee JH, Zoll WL, Merrick WC, Dever TE. Promotion of met-tRNAiMet binding to ribosomes by yIF2, a bacterial IF2 homolog in yeast. Science. 1998 Jun 12;280(5370):1757-60. PubMed PMID: 9624054.
  • Dever TE, Sripriya R, McLachlin JR, Lu J, Fabian JR, Kimball SR, Miller LK. Disruption of cellular translational control by a viral truncated eukaryotic translation initiation factor 2alpha kinase homolog. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4164-9. PubMed PMID: 9539707; PubMed Central PMCID: PMC22459.
  • Richter-Cook NJ, Dever TE, Hensold JO, Merrick WC. Purification and characterization of a new eukaryotic protein translation factor. Eukaryotic initiation factor 4H. J Biol Chem. 1998 Mar 27;273(13):7579-87. PubMed PMID: 9516461.
  • Kawagishi-Kobayashi M, Silverman JB, Ung TL, Dever TE. Regulation of the protein kinase PKR by the vaccinia virus pseudosubstrate inhibitor K3L is dependent on residues conserved between the K3L protein and the PKR substrate eIF2alpha. Mol Cell Biol. 1997 Jul;17(7):4146-58. PubMed PMID: 9199350; PubMed Central PMCID: PMC232268.
  • Gale MJ Jr, Korth MJ, Tang NM, Tan SL, Hopkins DA, Dever TE, Polyak SJ, Gretch DR, Katze MG. Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein. Virology. 1997 Apr 14;230(2):217-27. PubMed PMID: 9143277.
  • Dever TE. Using GCN4 as a reporter of eIF2 alpha phosphorylation and translational regulation in yeast. Methods. 1997 Apr;11(4):403-17. PubMed PMID: 9126554.
  • Dever TE, Yang W, Aström S, Byström AS, Hinnebusch AG. Modulation of tRNA(iMet), eIF-2, and eIF-2B expression shows that GCN4 translation is inversely coupled to the level of eIF-2.GTP.Met-tRNA(iMet) ternary complexes. Mol Cell Biol. 1995 Nov;15(11):6351-63. PubMed PMID: 7565788; PubMed Central PMCID:
    PMC230887.
  • Dever TE, Wei CL, Benkowski LA, Browning K, Merrick WC, Hershey JW. Determination of the amino acid sequence of rabbit, human, and wheat germ protein synthesis factor eIF-4C by cloning and chemical sequencing. J Biol Chem. 1994 Feb 4;269(5):3212-8. PubMed PMID: 8106356.
  • Vazquez de Aldana CR, Dever TE, Hinnebusch AG. Mutations in the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2 alpha) that overcome the inhibitory effect of eIF-2 alpha phosphorylation on translation initiation. Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7215-9. PubMed PMID: 8102207; PubMed Central PMCID: PMC47107.
  • Barber GN, Wambach M, Wong ML, Dever TE, Hinnebusch AG, Katze MG. Translational regulation by the interferon-induced double-stranded-RNA-activated 68-kDa protein kinase. Proc Natl Acad Sci U S A. 1993 May 15;90(10):4621-5. PubMed PMID: 8099444; PubMed Central PMCID: PMC46564.
  • Dever TE, Chen JJ, Barber GN, Cigan AM, Feng L, Donahue TF, London IM, Katze MG, Hinnebusch AG. Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast. Proc Natl Acad Sci U S A. 1993 May 15;90(10):4616-20. PubMed PMID: 8099443; PubMed Central PMCID: PMC46563.
  • Hughes DL, Dever TE, Merrick WC. Further biochemical characterization of rabbit reticulocyte eIF-4B. Arch Biochem Biophys. 1993 Mar;301(2):311-9. PubMed PMID: 8460942.
  • Wek RC, Cannon JF, Dever TE, Hinnebusch AG. Truncated protein phosphatase GLC7 restores translational activation of GCN4 expression in yeast mutants defective for the eIF-2 alpha kinase GCN2. Mol Cell Biol. 1992 Dec;12(12):5700-10. PubMed PMID: 1333044; PubMed Central PMCID: PMC360510.
  • Dever TE, Feng L, Wek RC, Cigan AM, Donahue TF, Hinnebusch AG. Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast. Cell. 1992 Feb 7;68(3):585-96. PubMed PMID: 1739968.
  • Jaramillo M, Dever TE, Merrick WC, Sonenberg N. RNA unwinding in translation: assembly of helicase complex intermediates comprising eukaryotic initiation factors eIF-4F and eIF-4B. Mol Cell Biol. 1991 Dec;11(12):5992-7. PubMed PMID: 1719376; PubMed Central PMCID: PMC361763.
  • Morley SJ, Dever TE, Etchison D, Traugh JA. Phosphorylation of eIF-4F by protein kinase C or multipotential S6 kinase stimulates protein synthesis at initiation. J Biol Chem. 1991 Mar 15;266(8):4669-72. PubMed PMID: 2002015.
  • Tahara SM, Dietlin TA, Dever TE, Merrick WC, Worrilow LM. Effect of eukaryotic initiation factor 4F on AUG selection in a bicistronic mRNA. J Biol Chem. 1991 Feb 25;266(6):3594-601. PubMed PMID: 1995620.
  • Conroy SC, Dever TE, Owens CL, Merrick WC. Characterization of the 46,000-dalton subunit of eIF-4F. Arch Biochem Biophys. 1990 Nov 1;282(2):363-71. PubMed PMID: 2241157.
  • Merrick WC, Dever TE, Kinzy TG, Conroy SC, Cavallius J, Owens CL. Characterization of protein synthesis factors from rabbit reticulocytes. Biochim Biophys Acta. 1990 Aug 27;1050(1-3):235-40. PubMed PMID: 2207148.
  • Goss DJ, Carberry SE, Dever TE, Merrick WC, Rhoads RE. A fluorescence study of the interaction of protein synthesis initiation factors 4A, 4E, and 4F with mRNA and oligonucleotide analogs. Biochim Biophys Acta. 1990 Aug 27;1050(1-3):163-6. PubMed PMID: 2207140.
  • Jaramillo M, Browning K, Dever TE, Blum S, Trachsel H, Merrick WC, Ravel JM, Sonenberg N. Translation initiation factors that function as RNA helicases from mammals, plants and yeast. Biochim Biophys Acta. 1990 Aug 27;1050(1-3):134-9. PubMed PMID: 2169888.
  • Smith MR, Jaramillo M, Liu YL, Dever TE, Merrick WC, Kung HF, Sonenberg N. Translation initiation factors induce DNA synthesis and transform NIH 3T3 cells. New Biol. 1990 Jul;2(7):648-54. PubMed PMID: 2083255.
  • Tuazon PT, Morley SJ, Dever TE, Merrick WC, Rhoads RE, Traugh JA. Association of initiation factor eIF-4E in a cap binding protein complex (eIF-4F) is critical for and enhances phosphorylation by protein kinase C. J Biol Chem. 1990 Jun 25;265(18):10617-21. PubMed PMID: 2355012.
  • Goss DJ, Carberry SE, Dever TE, Merrick WC, Rhoads RE. Fluorescence study of the binding of m7GpppG and rabbit globin mRNA to protein synthesis initiation factors 4A, 4E, and 4F. Biochemistry. 1990 May 29;29(21):5008-12. PubMed PMID: 2378863.
  • Rozen F, Edery I, Meerovitch K, Dever TE, Merrick WC, Sonenberg N. Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F. Mol Cell Biol. 1990 Mar;10(3):1134-44. PubMed PMID: 2304461; PubMed Central PMCID: PMC360981.
  • Dever TE, Costello CE, Owens CL, Rosenberry TL, Merrick WC. Location of seven post-translational modifications in rabbit elongation factor 1 alpha including dimethyllysine, trimethyllysine, and glycerylphosphorylethanolamine. J Biol Chem. 1989 Dec 5;264(34):20518-25. PubMed PMID: 2511205.
  • Lawson TG, Lee KA, Maimone MM, Abramson RD, Dever TE, Merrick WC, Thach RE. Dissociation of double-stranded polynucleotide helical structures by eukaryotic initiation factors, as revealed by a novel assay. Biochemistry. 1989 May 30;28(11):4729-34. PubMed PMID: 2548591.
  • Rosenberry TL, Krall JA, Dever TE, Haas R, Louvard D, Merrick WC. Biosynthetic incorporation of 3Hethanolamine into protein synthesis elongation factor 1 alpha reveals a new post-translational protein modification. J Biol Chem. 1989 May 5;264(13):7096-9. PubMed PMID: 2708357.
  • Smit-McBride Z, Dever TE, Hershey JW, Merrick WC. Sequence determination and cDNA cloning of eukaryotic initiation factor 4D, the hypusine-containing protein. J Biol Chem. 1989 Jan 25;264(3):1578-83. PubMed PMID: 2492279.
  • Abramson RD, Dever TE, Merrick WC. Biochemical evidence supporting a mechanism for cap-independent and internal initiation of eukaryotic mRNA. J Biol Chem. 1988 May 5;263(13):6016-9. PubMed PMID: 2966150.
  • Abramson RD, Browning KS, Dever TE, Lawson TG, Thach RE, Ravel JM, Merrick WC. Initiation factors that bind mRNA. A comparison of mammalian factors with wheat germ factors. J Biol Chem. 1988 Apr 15;263(11):5462-7. PubMed PMID: 3356693.
  • Dever TE, Glynias MJ, Merrick WC. GTP-binding domain: three consensus sequence elements with distinct spacing. Proc Natl Acad Sci U S A. 1987 Apr;84(7):1814-8. PubMed PMID: 3104905; PubMed Central PMCID: PMC304531.
  • Abramson RD, Dever TE, Lawson TG, Ray BK, Thach RE, Merrick WC. The ATP-dependent interaction of eukaryotic initiation factors with mRNA. J Biol Chem. 1987 Mar 15;262(8):3826-32. PubMed PMID: 2950099.

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