A major effort of the Human Genetics Section, led by Bruce Howard, focuses on epigenome structure, including higher-order chromatin architecture and DNA methylation patterns. Special attention is devoted to how defects in the maintenance of epigenetic structures (or failures in programmed transitions, especially in the perinatal period) may underlie common developmental disorders and age-related diseases. Bioinformatic tools are developed and implemented to facilitate human genome annotation and pattern recognition/comparison searches of chromatin immunoprecipitation data, as well as analyses of microarray and next-generation sequencing data. Together, these genomics approaches are invaluable for identifying new features of developmental and age-related of epigenome remodeling.
- Porrás A, Kozar S, Russanova V, Salpea P, Hirai T, Sammons N, Mittal P, Kim JY, Ozato K, Romero R, Howard BH. Developmental and epigenetic regulation of the human TLR3 gene. Mol Immunol. 2008 Nov;46(1):27-36. Epub 2008 Aug 19.PMID: 18715647
- Humphrey GW, Wang YH, Hirai T, Padmanabhan R, Panchision DM, Newell LF, McKay RD, Howard BH. Complementary roles for histone deacetylases 1, 2, and 3 in differentiation of pluripotent stem cells. Differentiation. 2008 Apr;76(4):348-56. Epub 2007 Nov 15.PMID: 18021260
- Howard BH, Phillips CV, Matinhure N, Goodman KJ, McCurdy SA, Johnson CA. Barriers and incentives to orphan care in a time of AIDS and economic crisis: a cross-sectional survey of caregivers in rural Zimbabwe. BMC Public Health. 2006 Feb 9;6:27.PMID: 16469104
- McAlister AL, Howard BH. Cigarette taxes and their proposed uses: support among smokers and non-smokers in different income groups in Texas. Tob Control. 2005 Jun;14(3):213-4. No abstract available. PMID: 15923473
- Russanova VR, Hirai TH, Tchernov AV, Howard BH. Mapping development-related and age-related chromatin remodeling by a high throughput ChIP-HPLC approach. J Gerontol A Biol Sci Med Sci. 2004 Dec;59(12):1234-43. Erratum in: J Gerontol A Biol Sci Med Sci. 2005 Apr;60(4):411-2. PMID: 15699522