A major effort of the Human Genetics Section, led by Bruce Howard, focuses on epigenome structure, including higher-order chromatin architecture and DNA methylation patterns. Special attention is devoted to how defects in the maintenance of epigenetic structures (or failures in programmed transitions, especially in the perinatal period) may underlie common developmental disorders and age-related diseases. Bioinformatic tools are developed and implemented to facilitate human genome annotation and pattern recognition/comparison searches of chromatin immunoprecipitation data, as well as analyses of microarray and next-generation sequencing data. Together, these genomics approaches are invaluable for identifying new features of developmental and age-related of epigenome remodeling.

Selected Publications

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