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Eunice Kennedy Shriver National Institute of Child Health and Human Development - Program in Genomics of Differentiation

Michael Cashel Lab

Mike Cashel's Section on Molecular Regulation, many years ago, discovered the natural guanine nucleotide analogs ppGpp, which are now well known to function as second messengers.  In bacteria and plant kingdoms, (p)ppGpp regulates global gene expression, metabolic and physiological adjustments in response to nutritional and environmental sources of stress. In bacteria, (p)ppGpp is often required for expression of virulence genes in bacterial pathogens. The Section focuses on intersections between nutritional stress, metabolism, physiology and transcription regulation with approaches that center on microbial molecular genetics, biochemistry and bioinformatics.  We currently are exploring the possibility that biological diversity of (p)ppGpp synthetases and hydrolases generate new (p)ppGpp-like nucleotide regulators.  

Selected Publications