Paul Love in the Section on Cellular and Developmental Biology focuses on T lymphocyte development, particularly signal transduction molecules and pathways that regulate T cell maturation in the thymus. The group revealed a key difference in the subunit composition and signaling potential of the antigen receptors (TCRs) expressed on two distinct classes of T cells. Recently this group described a previously unknown T cell-specific protein, Themis, that functions during late stages of T cell maturation. In studying molecules that control T cell migration and trafficking, the group discovered a critical function for the chemokine receptor CCR9 in regulating the migration of developing T cells to and within the thymus. Additional studies have focused on the role of the LIM domain protein Ldb1 in hematopoiesis.

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