Paul Love in the Section on Cellular and Developmental Biology focuses on T lymphocyte development, particularly signal transduction molecules and pathways that regulate T cell maturation in the thymus. The group revealed a key difference in the subunit composition and signaling potential of the antigen receptors (TCRs) expressed on two distinct classes of T cells. Recently this group described a previously unknown T cell-specific protein, Themis, that functions during late stages of T cell maturation. In studying molecules that control T cell migration and trafficking, the group discovered a critical function for the chemokine receptor CCR9 in regulating the migration of developing T cells to and within the thymus. Additional studies have focused on the role of the LIM domain protein Ldb1 in hematopoiesis.
- Love PE, Hayes SM. ITAM-mediated signaling by the T-cell antigen receptor. Cold Spring Harb Perspect Biol. 2010 Jun 1;2(6):a002485. PMID: 20516133
- Li L, Lee JY, Gross J, Song SH, Dean A, Love PE. A requirement for Lim domain binding protein 1 in erythropoiesis. J Exp Med. 2010 Nov 1. PMID: 21041453
- Lesourne R, Uehara S, Lee J, Song KD, Li L, Pinkhasov J, Zhang Y, Weng NP, Wildt KF, Wang L, Bosselut R, Love PE. Themis, a T cell-specific protein important for late thymocyte development. Nat Immunol. 2009 Aug;10(8):840-7. PMID: 19597498
- Hayes SM, Li L, Love PE. TCR signal strength influences alphabeta/gammadelta lineage fate. Immunity. 2005 May;22(5):583-93. PMID: 15894276
- Sommers CL, Park CS, Lee J, Feng C, Fuller CL, Grinberg A, Hildebrand JA, Lacaná E, Menon RK, Shores EW, Samelson LE, Love PE. A LAT mutation that inhibits T cell development yet induces lymphoproliferation. Science. 2002 Jun 14;296(5575):2040-3. PMID: 12065840