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Pacak Lab: Section on Medical Neuroendocrinology

Developmental Endocrine Oncology and Genetics

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Contact

Karel Pacak, MD, PhD, DSc

karel pacak

Phone: 301-402-4594

Email: karel@mail.nih.gov

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Building 10, Room 1-3140
10 Center Drive
Bethesda, MD 20892

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Publications

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  • Created by Swan, Jeremy (NIH/OD) [C], last modified by Unknown User (knuemm) on Apr 21, 2020
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Dr. Pacak has co-authored more than 300 articles, 170 scientific abstracts, and 70 textbook chapters. Also, he is a reviewer of over 25 international medical journals, including Endocrine Journal, NEJM, JCEM and others.

Selected articles

Antonio K, Valdez MMN, Mercado-Asis L, Taïeb D, Pacak K. Pheochromocytoma/paraganglioma: recent updates in genetics, biochemistry, immunohistochemistry, metabolomics, imaging and therapeutic options. Gland Surg. 2020 Feb;9(1):105-123.

Yu J, Shi X, Yang C, Bullova P, Hong CS, Nesvick CL, Dmitriev P, Pacak K, Zhuang Z, Cao H, Li L. A novel germline gain-of-function HIF2A mutation in hepatocellular carcinoma with polycythemia. Aging (Albany NY). 2020 Apr 1;12.

Jha A, Patel M, Baker E, Gonzales MK, Ling A, Millo C, Knue M, Civelek AC, Pacak K. Role of 68Ga-DOTATATE PET/CT in a Case of SDHB-Related Pterygopalatine Fossa Paraganglioma Successfully Controlled with Octreotide. Nucl Med Mol Imaging. 2020 Feb;54(1):48-52.

Taieb D, Pacak K. Genetic determinants of pheochromocytoma and paraganglioma imaging phenotypes. J Nucl Med. 2020 Mar 20 pii:jnumed.120.245613.

Liu Y, Pang Y, Zhu B, Uher O, Caisova V, Huynh TT, Taïeb D, Hadrava Vanova K, Ghayee HK, Neuzil J, Levine M, Yang C, Pacak K. Therapeutic targeting of SDHB-mutated pheochromocytoma/paraganglioma with pharmacologic ascorbic acid. Clin Cancer Res. 2020 Mar9:clincanres.2335.2019.

Jochmanova I, Abcede AMT, Guerrero RJS, Malong CLP, Wesley R, Huynh T, Gonzales MK, Wolf KI, Jha A, Knue M, Prodanov T, Nilubol N, Mercado-Asis LB, Stratakis CA, Pacak K. Clinical characteristics and outcomes of SDHB-related pheochromocytoma and paraganglioma in children and adolescents. J Cancer Res Clin Oncol. 2020 Apr;146(4):1051-1063.

Tepede AA, Welch J, Lee M, Mandl A, Agarwal SK, Nilubol N, Patel D, Cochran C, Simonds WF, Weinstein LS, Jha A, Millo C, Pacak K, Blau JE. 18F-FDOPA PET/CT accurately identifies MEN1-associated pheochromocytoma. Endocrinol Diabetes Metab Case Rep. 2020 Mar 3;2020. pii: EDM190156.

Abdallah A, Pappo A, Reiss U, Shulkin BL, Zhuang Z, Pacak K, Bahrami A. Clinical manifestations of Pacak-Zhuang syndrome in a male pediatric patient. Pediatr Blood Cancer. 2020 Apr;67(4):e28096.

Jha A, Nilubol N, Pacak K. Some Considerations in Treating Malignant Head and Neck Paragangliomas. JAMA Otolaryngol Head Neck Surg. 2019 Nov 14.

Mamilla D, Gonzales MK, Esler MD, Pacak K. Pseudopheochromocytoma. Endocrinol Metab Clin North Am. 2019 Dec;48(4):751-764.

Nölting S, Ullrich M, Pietzsch J, Ziegler CG, Eisenhofer G, Grossman A, Pacak K. Current Management of Pheochromocytoma/Paraganglioma: A Guide for the Practicing Clinician in the Era of Precision Medicine. Cancers (Basel). 2019 Oct 8;11(10):1505.

Taïeb D, Jha A, Treglia G, Pacak K. Molecular imaging and radionuclide therapy of pheochromocytoma and paraganglioma in the era of genomic characterization of disease subgroups. Endocr Relat Cancer. 2019 Nov;26(11):R627-R652.

Pacak K, Taïeb D. Pheochromocytoma (PHEO) and Paraganglioma (PGL). Cancers (Basel). 2019 Sep 18;11(9):1391.

Kantorovich V, Pacak K. Emergencies Related to Pheochromocytoma/Paraganglioma Syndrome. 2019 Aug 29. In: Feingold KR, Anawalt B, Boyce A, Chrousos G, Dungan K, Grossman A, Hershman JM, Kaltsas G, Koch C, Kopp P, Korbonits M, McLachlan R, Morley JE, New M, Perreault L, Purnell J, Rebar R, Singer F, Trence DL, Vinik A, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000–.

Mamilla D, Araque KA, Brofferio A, Gonzales MK, Sullivan JN, Nilubol N, Pacak K. Postoperative Management in Patients with Pheochromocytoma and Paraganglioma. Cancers (Basel). 2019 Jul 3;11(7):936.

Guha A, Musil Z, Vicha A, Zelinka T, Pacak K, Astl J, Chovanec M. A systematic review on the genetic analysis of paragangliomas: primarily focused on head and neck paragangliomas. Neoplasma. 2019 Jun 29;66(5):671-680.

Pang Y, Liu Y, Pacak K, Yang C. Pheochromocytomas and Paragangliomas: From Genetic Diversity to Targeted Therapies. Cancers (Basel). 2019 Mar 28;11(4):436.


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