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Eunice Kennedy Shriver National Institute of Child Health and Human Development - Program in Reproductive and Adult Endocrinology
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Section on Reproductive Medicine (SRM)

Head: Lynnette Nieman, M.D.

Dr Nieman has short blond hair and is smiling a beautiful heartfelt smile
The Section on Reproductive Medicine (SRM), led by Dr. Lynnette Nieman, published a landmark article in Endocrine Reviews on the hypothalamic pituitary adrenal axis (HPA) in pregnancy; during pregnancy, diagnosis of HPA disorders presents a challenge. The section completed a study comparing immunometric and radioimmunoassay measurement of ACTH for differential diagnosis of Cushing's syndrome. The section continues to work on the diagnosis and management of patients with hypercortisolism, recently focusing on the diagnosis and management of ectopic ACTH-secreting tumors and their localization. The section also investigates endometrial physiology and endometriosis pathologies. It has published studies on the endometrium, describing the localization of lesions in women with endometriosis and characterizing the estrogen alpha receptor and use of raloxifene as an adjunctive treatment for endometriosis. CD10 cell-surface metalloendopeptidase is present in normal endometrium, and staining of the protein is helpful in diagnosing endometriosis.

10 Most Recent Publications

Overcoming burdens in the regulation of clinical research in children. Proceedings of a consensus conference, in historical context.
Levine RJ, Genel M, Cuttler L, Becker DJ, Nieman L, Rosenfield RL.
Int J Pediatr Endocrinol. 2011 Dec 30;2011(1):19.
PMID:22208165

Adrenal insufficiency: etiology, diagnosis and treatment.
Neary N, Nieman L.
Curr Opin Endocrinol Diabetes Obes. 2010 Jun;17(3):217-23. Review.
PMID:20375886

Technical details influence the diagnostic accuracy of the 1 microg ACTH stimulation test.
Wade M, Baid S, Calis K, Raff H, Sinaii N, Nieman L.
Eur J Endocrinol. 2010 Jan;162(1):109-13. Epub 2009 Oct 1.
PMID:19797501

WITHDRAWN: The diagnosis of Cushing's syndrome: an endocrine society clinical practice guideline.
Nieman L, Biller B, Findling J, Newell-Price J, Savage M, Stewart P, Montori VM.
Eur J Endocrinol. 2009 Aug 18. [Epub ahead of print]
PMID:19690086

Management of endocrine manifestations and the use of mitotane as a chemotherapeutic agent for adrenocortical carcinoma.
Veytsman I, Nieman L, Fojo T.
J Clin Oncol. 2009 Sep 20;27(27):4619-29. Epub 2009 Aug 10. Review.
PMID:19667279

Iatrogenic Cushing syndrome after epidural triamcinolone injections in an HIV type 1-infected patient receiving therapy with ritonavir-lopinavir.
Ramanathan R, Pau AK, Busse KH, Zemskova M, Nieman L, Kwan R, Hammer JH, Mican JM, Maldarelli F.
Clin Infect Dis. 2008 Dec 15;47(12):e97-9.
PMID:18991509

Editorial: The dexamethasone-suppressed corticotropin-releasing hormone test for the diagnosis of Cushing's syndrome: what have we learned in 14 years?
Nieman L.
J Clin Endocrinol Metab. 2007 Aug;92(8):2876-8. No abstract available.
PMID:17682087

Expression of the proto-oncoprotein breast cancer nuclear receptor auxiliary factor (Brx) is altered in eutopic endometrium of women with endometriosis.
Hearns-Stokes R, Mayers C, Zahn C, Cruess D, Gustafsson JA, Segars J, Nieman L.
Fertil Steril. 2006 Jan;85(1):63-70.
PMID:16412732

Testosterone suppression of CRH-stimulated cortisol in men.
Rubinow DR, Roca CA, Schmidt PJ, Danaceau MA, Putnam K, Cizza G, Chrousos G, Nieman L.
Neuropsychopharmacology. 2005 Oct;30(10):1906-12.
PMID:15841103

Optical sectioning using a fiber probe with an angled illumination-collection geometry: evaluation in engineered tissue phantoms.
Nieman L, Myakov A, Aaron J, Sokolov K.
Appl Opt. 2004 Feb 20;43(6):1308-19.
PMID:15008534

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