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Eunice Kennedy Shriver National Institute of Child Health and Human Development - Program in Reproductive and Adult Endocrinology
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Section on Reproductive Medicine (SRM)

Head: Lynnette Nieman, M.D.

Dr Nieman has short blond hair and is smiling a beautiful heartfelt smile
The Section on Reproductive Medicine (SRM), led by Dr. Lynnette Nieman, published a landmark article in Endocrine Reviews on the hypothalamic pituitary adrenal axis (HPA) in pregnancy; during pregnancy, diagnosis of HPA disorders presents a challenge. The section completed a study comparing immunometric and radioimmunoassay measurement of ACTH for differential diagnosis of Cushing's syndrome. The section continues to work on the diagnosis and management of patients with hypercortisolism, recently focusing on the diagnosis and management of ectopic ACTH-secreting tumors and their localization. The section also investigates endometrial physiology and endometriosis pathologies. It has published studies on the endometrium, describing the localization of lesions in women with endometriosis and characterizing the estrogen alpha receptor and use of raloxifene as an adjunctive treatment for endometriosis. CD10 cell-surface metalloendopeptidase is present in normal endometrium, and staining of the protein is helpful in diagnosing endometriosis.

10 Most Recent Publications

Different imaging characteristics of concurrent pituitary adenomas in a patient with Cushing's disease.
Mehta GU, Montgomery BK, Raghavan P, Sharma S, Nieman LK, Patronas N, Oldfield EH, Chittiboina P.
J Clin Neurosci. 2015 May;22(5):891-4. doi: 10.1016/j.jocn.2015.01.001. Epub 2015 Mar 29.
PMID: 25827866

Comorbidities in Cushing's disease.
Sharma ST, Nieman LK, Feelders RA.
Pituitary. 2015 Apr;18(2):188-94. doi: 10.1007/s11102-015-0645-6.
PMID: 25724314

Primary vs secondary adrenal insufficiency: ACTH-stimulated aldosterone diagnostic cut-off values by tandem mass spectrometry.
Abraham SB, Abel BS, Sinaii N, Saverino E, Wade M, Nieman LK.
Clin Endocrinol (Oxf). 2015 Jan 24. doi: 10.1111/cen.12726.
PMID: 25620457

A phase 2 study of Chronocort, a modified-release formulation of hydrocortisone, in the treatment of adults with classic congenital adrenal hyperplasia.
Mallappa A, Sinaii N, Kumar P, Whitaker MJ, Daley LA, Digweed D, Eckland DJ, Van Ryzin C, Nieman LK, Arlt W, Ross RJ, Merke DP.
J Clin Endocrinol Metab. 2015 Mar;100(3):1137-45. doi: 10.1210/jc.2014-3809. Epub 2014 Dec 11.
PMID: 25494662

Urine free cortisol in the diagnosis of Cushing's syndrome: is it worth doing and, if so, how?
Raff H, Auchus RJ, Findling JW, Nieman LK.
J Clin Endocrinol Metab. 2015 Feb;100(2):395-7. doi: 10.1210/jc.2014-3766. Epub 2014 Nov 25. No abstract available.
PMID: 25423573

Hypothalamic-pituitary-adrenal axis in lethal canine Staphylococcus aureus pneumonia.
Cort├ęs-Puch I, Hicks CW, Sun J, Solomon SB, Eichacker PQ, Sweeney DA, Nieman LK, Whitley EM, Behrend EN, Natanson C, Danner RL.
Am J Physiol Endocrinol Metab. 2014 Dec 1;307(11):E994-E1008. doi: 10.1152/ajpendo.00345.2014. Epub 2014 Oct 7.
PMID: 25294215

Physiological basis for the etiology, diagnosis, and treatment of adrenal disorders: Cushing's syndrome, adrenal insufficiency, and congenital adrenal hyperplasia.
Raff H, Sharma ST, Nieman LK.
Compr Physiol. 2014 Apr;4(2):739-69. doi: 10.1002/cphy.c130035. Review.
PMID: 24715566

Pitfalls in the diagnosis and differential diagnosis of Cushing's syndrome.
Nieman L.
Clin Endocrinol (Oxf). 2014 Mar;80(3):333-4. doi: 10.1111/cen.12362. Epub 2013 Dec 5. No abstract available.
PMID: 24303816

Is prolactin measurement of value during inferior petrosal sinus sampling in patients with adrenocorticotropic hormone-dependent Cushing's Syndrome?
Sharma ST, Nieman LK.
J Endocrinol Invest. 2013 Dec;36(11):1112-6. doi: 10.3275/9067. Epub 2013 Jul 26. Review.
PMID: 23887034 Free PMC Article

Update in the medical therapy of Cushing's disease.
Nieman LK.
Curr Opin Endocrinol Diabetes Obes. 2013 Aug;20(4):330-4. doi: 10.1097/MED.0b013e3283631809. Review.
PMID: 23807605

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