Head: James Segars, M.D.
Dr. James Segars heads the Unit on Reproductive Endocrinology and Infertility (UREI). The laboratory addresses disparities in access to reproductive services and treatment. Collaborative work established a complex relationship between the BRX gene complex and fibroid generation, and the laboratory is expanding its work on several aspects of fibroids, including gene regulation and growth factors. The primary hypothesis posits that fibroid growth is in some way associated with attempts at healing and inflammation. With regard to fertility, the Walter Reed Army Medical Center's Assisted Reproductive Technologies Program continues to provide material for clinical studies. In addition to continuing to capitalize on and encourage work already in progress, the Center plans to enlarge its consultative service; to increase the number of fellowships to three per year (already approved), thus making Walter Reed's fellowship program the largest Reproductive Endocrinology and Infertility Fellowship Program in the country; and to develop several protocols, including one on abnormal bleeding mechanisms and treatment. A major effort will focus on treating patients diagnosed with cancer who wish to preserve fertility through the use of various drug regimens. In addition, the oocyte physician program is almost entirely in place, involving investigators at the NIH and in Livingston, New Jersey.
10 Most Recent Publications
DNA methylome and transcriptome sequencing in human ovarian granulosa cells links age-related changes in gene expression to gene body methylation and 3'-end GC density.
Yu B, Russanova VR, Gravina S, Hartley S, Mullikin JC, Ignezweski A, Graham J, Segars JH, DeCherney AH, Howard BH.
Oncotarget. 2015 Feb 28;6(6):3627-43.
GnRH agonist reduces estrogen receptor dimerization in GT1-7 cells: Evidence for cross-talk between membrane-initiated estrogen and GnRH signaling.
Chason RJ, Kang JH, Gerkowicz SA, Dufau ML, Catt KJ, Segars JH.
Mol Cell Endocrinol. 2015 Mar 15;404:67-74. doi: 10.1016/j.mce.2015.01.023. Epub 2015 Jan 22.
Gonadotropin surge-inhibiting/attenuating factors: a review of current evidence, potential applications, and future directions for research.
Vega MG, Zarek SM, Bhagwat M, Segars JH.
Mol Reprod Dev. 2015 Jan;82(1):2-16. doi: 10.1002/mrd.22439. Epub 2015 Jan 12.
Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review.
Pacis MM, Fortin CN, Zarek SM, Mumford SL, Segars JH.
J Assist Reprod Genet. 2015 Mar;32(3):323-35. doi: 10.1007/s10815-014-0407-9. Epub 2014 Dec 30.
Dynamic reciprocity between cells and their microenvironment in reproduction.
Thorne JT, Segal TR, Chang S, Jorge S, Segars JH, Leppert PC.
Biol Reprod. 2015 Jan;92(1):25. doi: 10.1095/biolreprod.114.121368. Epub 2014 Nov 19.
Uterine fibroid research: a work in progress.
Reprod Sci. 2014 Sep;21(9):1065-6. doi: 10.1177/1933719114546644. No abstract available.
The extracellular matrix contributes to mechanotransduction in uterine fibroids.
Leppert PC, Jayes FL, Segars JH.
Obstet Gynecol Int. 2014;2014:783289. doi: 10.1155/2014/783289. Epub 2014 Jul 3. Review.
Leiomyoma cells in 3-dimensional cultures demonstrate an attenuated response to fasudil, a rho-kinase inhibitor, when compared to 2-dimensional cultures.
Malik M, Britten J, Segars J, Catherino WH.
Reprod Sci. 2014 Sep;21(9):1126-38. doi: 10.1177/1933719114545240. Epub 2014 Aug 1.
Mechanical signaling in reproductive tissues: mechanisms and importance.
Jorge S, Chang S, Barzilai JJ, Leppert P, Segars JH.
Reprod Sci. 2014 Sep;21(9):1093-107. doi: 10.1177/1933719114542023. Epub 2014 Jul 6. Review.
Use of dietary phytochemicals to target inflammation, fibrosis, proliferation, and angiogenesis in uterine tissues: promising options for prevention and treatment of uterine fibroids?
Islam MS, Akhtar MM, Ciavattini A, Giannubilo SR, Protic O, Janjusevic M, Procopio AD, Segars JH, Castellucci M, Ciarmela P.
Mol Nutr Food Res. 2014 Aug;58(8):1667-84. doi: 10.1002/mnfr.201400134. Epub 2014 Jun 30. Review.