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Eunice Kennedy Shriver National Institute of Child Health and Human Development - Program in Reproductive and Adult Endocrinology
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Unit on Reproductive Endocrinology and Infertility (UREI)

Head: James Segars, M.D.

Dr Segars is smiling.  He has thick auburn hair and is wearing glasses a blue shirt and tie under a white lab coat.
Dr. James Segars heads the Unit on Reproductive Endocrinology and Infertility (UREI). The laboratory addresses disparities in access to reproductive services and treatment. Collaborative work established a complex relationship between the BRX gene complex and fibroid generation, and the laboratory is expanding its work on several aspects of fibroids, including gene regulation and growth factors. The primary hypothesis posits that fibroid growth is in some way associated with attempts at healing and inflammation. With regard to fertility, the Walter Reed Army Medical Center's Assisted Reproductive Technologies Program continues to provide material for clinical studies. In addition to continuing to capitalize on and encourage work already in progress, the Center plans to enlarge its consultative service; to increase the number of fellowships to three per year (already approved), thus making Walter Reed's fellowship program the largest Reproductive Endocrinology and Infertility Fellowship Program in the country; and to develop several protocols, including one on abnormal bleeding mechanisms and treatment. A major effort will focus on treating patients diagnosed with cancer who wish to preserve fertility through the use of various drug regimens. In addition, the oocyte physician program is almost entirely in place, involving investigators at the NIH and in Livingston, New Jersey.

10 Most Recent Publications

Use of PET/CT with Cosyntropin Stimulation to Identify and Localize Adrenal Rest Tissue following Adrenalectomy in a Woman with Congenital Adrenal Hyperplasia.
Crocker MK, Barak S, Millo CM, Beall SA, Niyyati M, Chang R, Avila NA, Van Ryzin C, Segars J, Quezado M, Merke DP.
J Clin Endocrinol Metab. 2012 Aug 17. [Epub ahead of print]

Preconception stress and the secondary sex ratio: a prospective cohort study.
Chason RJ, McLain AC, Sundaram R, Chen Z, Segars JH, Pyper C, Louis GM.
Fertil Steril. 2012 Aug 7. [Epub ahead of print]

GnRH antagonist rescue in high responders at risk for OHSS results in excellent assisted reproduction outcomes.
Hill MJ, Chason RJ, Payson MD, Segars JH, Csokmay JM.
Reprod Biomed Online. 2012 May 23. [Epub ahead of print]

Leiomyoma: genetics, assisted reproduction, pregnancy and therapeutic advances.
Levy G, Hill MJ, Beall S, Zarek SM, Segars JH, Catherino WH.
J Assist Reprod Genet. 2012 May 15. [Epub ahead of print]

The estimated annual cost of uterine leiomyomata in the United States.
Cardozo ER, Clark AD, Banks NK, Henne MB, Stegmann BJ, Segars JH.
Am J Obstet Gynecol. 2012 Mar;206(3):211.e1-9. Epub 2011 Dec 11. Review.

The prevalence of genuine empty follicle syndrome.
Mesen TB, Yu B, Richter KS, Widra E, DeCherney AH, Segars JH.
Fertil Steril. 2011 Dec;96(6):1375-7.

Are there subtle genome-wide epigenetic alterations in normal offspring conceived by assisted reproductive technologies?
Batcheller A, Cardozo E, Maguire M, DeCherney AH, Segars JH.
Fertil Steril. 2011 Dec;96(6):1306-11. Epub 2011 Oct 26. Review.

Characterization of tissue biomechanics and mechanical signaling in uterine leiomyoma.
Norian JM, Owen CM, Taboas J, Korecki C, Tuan R, Malik M, Catherino WH, Segars JH.
Matrix Biol. 2012 Jan;31(1):57-65. Epub 2011 Sep 24.

Relating pelvic pain location to surgical findings of endometriosis.
Hsu AL, Sinaii N, Segars J, Nieman LK, Stratton P.
Obstet Gynecol. 2011 Aug;118(2 Pt 1):223-30.

Experience with a patient-friendly, mandatory, single-blastocyst transfer policy: the power of one.
Csokmay JM, Hill MJ, Chason RJ, Hennessy S, James AN, Cohen J, Decherney AH, Segars JH, Payson MD.
Fertil Steril. 2011 Sep;96(3):580-4. Epub 2011 Jul 20.

Dr Segars Pubmed Author Search