Building 49, 6C80
- 2000: BSc (Microbiology), Bangalore University, India.
- 2002: MSc (Microbiology), Bangalore University, India.
- 2007: Ph.D. (Neuroscience), Max Planck Institute for Experimental Medicine, Georg-August-University, Goettingen, Germany.
- 2008 — Present: Postdoctoral fellow, NICHD, National Institutes of Health, Bethesda, MD, USA.
As a post doctoral fellow from Jan 2008 to present, did a comprehensive analysis of Carboxypeptidase E splice variants and discovered that CPE-ΔN splice variant is a new prognostic marker for metastasis (Manuscript submitted).
For Doctoral training at Max Planck Institute for Experimental Medicine Goettingen, Germany, worked on Small conductance calcium activated potassium channel 2 (SK2) in mouse brain. Found five novel splice variants for SK2 channel by bioinformatics analysis, cloned and characterized the same (data published in J Neurochemistry). Found regulation of this splice variant at different physiological and disease conditions. I had a very broad understanding of neurobiology and its techniques during this period. Was a visiting student at John A. Burns School of Medicine,University of Hawaii.
From 2002 to 2004 worked as a Research Scientist at Institute Of Bioinformatics ITPL Bangalore India. Annotated more than 120 Human proteins for Human Protein Reference Database developed by Institute Of Bioinformatics data published in Genome Research. Worked on Manually Curated Functional Annotation of the Human X Chromosome, data published in Nature Genetics. Worked on a Bioinformatics Analysis of Protein Tyrosine Phosphatases in Humans, data published in journal DNA research. Worked on Protein interaction network maps for HPRD data published in Genome Research.
From 2001 to 2002 did a comprehensive analysis on "Human Genome Project" thesis titled "Survey on Human Genome Project" at Indian Institute Of Science, Bangalore for master's thesis project.
- 2004-2007: Max Planck Institute PhD fellowship
- 2008: Gordon conference young investigator award
- 2008: 5th-annual-NICHD Retreat-2009 award
- 2009: 15th International Symposium on Chromaffin Cell Biology fellowship award
- 2010: NIH Fellows Award for Research Excellence
- 2008: Gordon conference
- 2008: 5th-annual-NICHD Retreat-2009
- 2009: 15th International Symposium on Chromaffin Cell Biology
- Operating systems: Mac OS, Windows XP and Unix.
- Programming: Perl, Java script.
- Bioinformatics Skills: Well versed in most of the bioinformatics softwares, Data mining, annotations of genes and proteins, Genes and splice variants predictions, motif finding, interaction network construction and bioinformatics experimental designs.
- Molecular and cell biology: Well versed in most of the standard Molecular and cell biology techniques.
- Behavioral skills: Learning and memory paradigms and stress paradigms in mice.
- Lee TK, Murthy SR, Cawley NX, Dhanvantari S, Hewitt SM, Lou H, Lau T, Ma S, Huynh T, Wesley RA, Ng IO, Pacak K, Poon RT, Loh YP. An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers. J Clin Invest. 2011 Mar 1;121(3):880-92.
- Murthy SR, Pacak K, Loh YP. Carboxypeptidase E: elevated expression correlated with tumor growth and metastasis in pheochromocytomas and other cancers. Cell Mol Neurobiol. 2010 Nov;30(8):1377-81.
- Nijholt I§, Murthy SR§, Schnitzbauer U, Dolga AM, Todorovic C, Sherrin T, Kye MJ, Sabatier JM, Knaus HG, Spiess J, and Blank T. Small-Conductance Ca2+-activated Potassium Type 2 Channels Regulate the Formation of Contextual Fear Memory. (accepted)
- Sherrin T, Blank T, Saravana R*, Rayner M, Spiess J, Todorovic C. Region specific gene expression profile in mouse brain after chronic corticotropin releasing factor receptor 1 activation: the novel role for diazepam binding inhibitor in contextual fear conditioning. Neuroscience 2009 Aug 4; 162(1):14-22.
- Murthy SR, Teodorescu G, Nijholt IM, Dolga AM, Grissmer S, Spiess J, Blank T. Identification and characterization of a novel, shorter isoform of the small conductance Ca2+-activated K+ channel SK2. J Neurochem. 2008 Sep;106(6):2312-21.
- Murthy SR. Characterization of Small Conductance Ca2+-activated K+ Channel 2 Isoforms in Mouse Brain. Dissertation zur Erlangung des Doktortitels, angenommen von: Georg-August-Universität Göttingen, Molecular Biology & Neurosciences Program, 2007-11-01 (PhD thesis publication)
- Gandhi, T.K.B., Chandran, S., Peri, S., Saravana, R*., Amanchy, R., Prasad, T.S.K and Pandey, A. A bioinformatics analysis of protein tyrosine phosphatases in humans. DNA Research 12, 79-89 (2005).
- Harsha H. C., Saravana R* (19th author out of 33).,. Manually Curated Functional Annotation of the Human X Chromosome. Nature Genetics 37, 331-332 (2005).
- Peri, S., Saravana R* (27th author out of 38).,. A. Human Protein Reference Database as a Discovery Resource for Proteomics. Nucleic Acids Research 32, 497-501(2004).
- Peri, S., Saravana R* (27th author out of 53).,. Development of Human Protein Reference Database as an initial platform for approaching systems biology in humans. Genome Research 13, 2363-2371(2003).
§ Contributed equally to the work
*Saravana. R= Murthy SR
- Interaction Network Map of Proteins Involved in Learning and Memory under Non-Stressed and Stressed Conditions. Society for Neuroscience, Washington DC, November 2005.
- Interaction Network Map of Proteins Involved in Learning and Memory under Non-Stressed and Stressed Conditions in Mouse brain. JABSOM, Honolulu, Hawaii, March 2006.
- Cloning and characterization of a novel conserved splice variant of SK2 Channel (SK2sh). Society for Neuroscience, San Diego, November 2007.
- A Carboxypeptidase E isoform Controls and Predicts Metastatic Potential of Human Cancers. Gordon conference, London, New Hampshire, July 2008. (This abstract was selected for invited talk on hot topics)
- A Splice Isoform of Carboxypeptidase E Promotes and Predicts Metastasis in Human Cancers. 5th Annual NICHD Retreat, Warrenton, Virginia April 2009
- A Carboxypeptidase E isoform Controls and Predicts Metastatic Potential of Human Cancers. Molecular Targets for Cancer Prevention Conference, NIH campus, Bethesda, February 2009.
- A Splice Isoform of Carboxypeptidase E Promotes and Predicts Metastasis in Human Cancers. FARE 2010. (Won FARE award for 2010).
- Carboxypeptidase E as a biomarker for predicting metastasis in pheochromocytomas. 15th International Symposium on Chromaffin Cell Biology, Mérida,Yucatán, México November 12-16, 2009
- A Splice Variant of Obesity Susceptibility gene Carboxypeptidase E Drives Tumor Metastasis in Human Cancers. 10th Annual CCR Fellows and Young Investigators Colloquium. Hershey, PA. March 19, 2010.