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Eunice Kennedy Shriver National Institute of Child Health and Human Development - Section on Neuronal Connectivity - Dr. Chi-Hon Lee Lab
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Melnattur, K.V., Pursley, R., Lin, T.-Y., Ting, C.-Y., Smith, P.D., Pohida, T. and Lee, C.-H. (2014) Multiple Redundant Medulla Projection Neurons Mediate Color Vision in Drosophila. J. Neurogenetics (doi:10.3109/01677063.2014.891590) (PDF).

Shinomiya, K., Karuppudurai, T., Lin, T.-Y., Lu, Z., Lee, C.-H., Meinertzhagen, I.A. (2014) Candidate Neural Substrates for Off-Edge Motion Detection in Drosophila. Curr Biol. 10:1062-70. (PDF). (Dispatch)

Ting, C.-Y., McQueen, P. G., Pandya, N., Lin, T.-Y., Yang, M., Reddy, O. V., O’Connor, M. B., McAuliffe, M. and Lee, C.-H. (2014) Photoreceptor-Derived Activin Promotes Dendritic Termination and Restricts the Receptive Fields of First-Order Interneurons in Drosophila. Neuron 81: 830-46. (PDF).

Karuppudurai, T., Lin, T.-Y., Ting, C.-Y., Pursley. R., Melnattur, K. V., Diao, F., White, B. H., Macpherson, L. J., Gallio,M., Pohida, T. and Lee, C.-H. (2014) A Hard-wired Glutamatergic Circuit Pools and Relays UV Signals to Mediate Spectral Preference in Drosophila. Neuron 81: 603-615. (PDF, Video abstract) (Recommended in F1000Prime).

Kundu, M., Kuzin, A., Lin, T.-Y., Lee, C.-H., Brody, T., Odenwald, WF. (2013) cis-Regulatory Complexity within a Large Non-Coding Region in the Drosophila Genome. PLOS one 8: e60137. (PDF)

Meinertzhagen, I.A and Lee, C.-H. (2012) The Genetic Analysis of Functional Connectomics in Drosophila. Adv Genet 80: 99-151. (PDF). 

Wardill, T.J., List, O., Li, X., Dongre, S., McCulloch, M., Ting, C.-Y., O’Kane, C. J., Tang, S., Lee, C.-H., Hardie, R. C., Juusola, M. (2012) Multiple Spectral Inputs Contribute to Motion Discrimination in the Drosophila Visual System. Science 336: 925-931.(PDF).

Brody, T., Yavatkar, A.S., Kuzin, A., Kundu, M., Tyson, L.J., Ross. J., Lin, T.-Y., Lee, C.-H., Awasaki, T., Lee, T., Odenwald. W.F. (2012) Use of a Drosophila genome-wide conserved sequence database to identify functionally related cis-regulatory enhancers. Dev Dyn 241: 169-189. (PDF).

Takemura, S., Karuppudurai,  T., Ting, C.-Y., Lu,  Z., Lee, C.-H.,# Meinertzhagen, I.A.# (2011) Cholinergic circuits integrate neighboring visual signals in a Drosophila motion detection pathway. Curr Biol. 21: 2077-2084. (PDF) (Dispatch).

Melnattur, K.V. and Lee, C.-H. (2011) Visual Circuit Assembly in Drosophila. Dev Neurobiol 36: 1286-96 (PDF).

Ting, C.-Y., Gu, S., Guttikonda, S., Lin, T.-Y., White, B.H., Lee, C.-H. (2011) Focusing transgene expression in Drosophila by coupling Gal4 with a novel split-LexA expression system. Genetics 188: 229-233 (PDF).

Lee, C.-H. (2010) The split view of motion. Nature 486: 178-179.(PDF)

Hsu, S.N., Yonekura, S, Ting, C.-Y., Robertson, H.M., Iwai, Y., Uemura, T., Lee, C.-H., Chiba, A. (2009) Conserved alternative splicing and expression patterns of arthropod N-cadherin. PLoS Genet 5: e1000441.(PDF)

Meinertzhagen, I.A., Takemura, S.-y., Lu, Z., Huang, S., Gao, S., Ting, C.-Y., Lee, C.-H. (2009) From form to function: the ways to know a neuron. J. Neurogenetics 29: 828-41.(PDF)

Gao, S., Takemura, S.-y., Ting, C.-Y., Huang, S., Lu, Z., Luan, H., Rister, J., Thum, A. S., Yang, M., Hong, S.-T., Wang, J.W., Odenwald, W.F., White, B.H., Meinertzhagen, I.A., Lee, C.-H. (2008) The Neural Substrate of Spectral Preference in Drosophila. Neuron 60, 328-42.(PDF)

Root, C.M., Masuyama, K., Green, D.S., Enell, L.E., Nassel, D.R., Lee, C.-H., Wang, J.W. (2008) A presynaptic gain control mechanism fine-tunes olfactory behavior. Neuron 59, 311-21.(PDF)

Ting, C.-Y., Herman, T., Yonekura S., Gao, S., Wang, J., Serpe, M., O'Connor, M.B., Zipursky, S.L., Lee, C.-H. (2007) Tiling of R7 axons in the Drosophila visual system is mediated both by transduction of an Activin signal to the nucleus and by mutual repulsion. Neuron 56: 793-806.(PDF) (Perspective)

Rister, J., Pauls, D., Schnell, B., Ting, C.-Y., Lee, C.-H., Sinakevitch, I., Morante, J., Strausfeld, N.J., Ito, K., Heisenberg, M. (2007) Dissection of the Peripheral Motion Channel in the Visual System of Drosophila melanogaster. Neuron 56, 155-70.(PDF)

Yonekura S., Lei Xu, Ting C.-Y., Lee C.-H. (2007) Adhesive but not signaling activity of Drosophila N-cadherin is essential for photoreceptor target selection. Dev Biol 304: 759-70.(PDF)

Ting C.-Y., Lee C.-H. (2007)Visual circuit development. Curr Opin Neurobiol 17: 65-72.(PDF)

Yonekura S., Ting C.-Y., Neves G., Hung K., Hsu S., Chiba A., Chess A., Lee C.-H. (2006) The variable transmembrane domain of Drosophila N-cadherin regulates adhesive activity. Mol Cell Biol 20: 6598-6608.(PDF , supp)

Pramatarova A, Ochalski PG, Lee C.-H., Howell B.W. (2006) Mouse disabled 1 regulates the nuclear position of neurons in a Drosophila eye model. Mol Cell Biol 26: 1510-7.(PDF)

Ting C.-Y., Yonekura S., Chung, P., Hsu, S., Robertson, H.M., Chiba, A., Lee, C.-H., (2005) Drosophila N-cadherin functions in the first stage of the two-stage layer-selection process of R7 photoreceptor afferents. Development 132: 953-963.(PDF,supp)

Lee, R. C., Clandinin, T.  R., Lee, C.-H., Chen, P.L., Meinertzhagen, I. A., Zipursky, S. L., (2003) The protocadherin Flamingo is required for axon target selection in the Drosophila visual system. Nat Neurosci 6: 557-63.(PDF,supp)

Clandinin, T. R., Lee, C.-H.*, Herman, T., Lee, R. C., Yang, A. Y., Ovasapyan, S., and Zipursky, S. L., (2001) Drosophila LAR regulates R1-R6 and R7 target specificity in the visual system. Neuron 32: 237-248.(PDF)

Lee, C.-H., Herman, T., Clandinin, T.R., Lee, R., Zipursky, S.L., (2001) N-cadherin regulates target specificity in the Drosophila visual system. Neuron 30: 437-50.(PDF)

Garrity, P.A., Lee, C.-H.*, Salecker, I., Robertson, H.C., Desai, C.J., Zinn, K. and Zipursky, S.L. (1999) Retinal axon target selection in Drosophila is regulated by a receptor protein tyrosine phosphatase. Neuron 22: 707-717.(PDF)

Lee, C.-H., Cowburn, D., Kuriyan, J. (1998) Peptide recognition mechanisms of eukaryotic signaling modules. Methods Mol. Biol 84: 3-31.

Zhang, Z., Lee, C.-H.*, Mandiyan, V., Borg, J.P., Margolis, B., Schlessinger, J., Kuriyan, J., (1997) Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain. EMBO J 16: 6141-6150.(PDF)

Moarefi, I., LaFeyre-Bernt., M., Sicheri, F., Huse, M., Lee, C.-H., Kuriyan, J., Miller, W.T. (1997) Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement. Nature 385: 650-653.(PDF)

Lee, C.-H., Saksela, K., Mirza, U., Chait, B. and Kuriyan, J. (1996) Crystal structure of the conserved core of HIV-1 Nef complexed with a Src-family SH3 domain. Cell 85: 931-942.(PDF)

Lee, C.-H., Leung, B., Lemmon, M.A., Zheng, J., Cowburn, D., Kuriyan, J. and Saksela, K. (1995) A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein. EMBO J 14: 5006-5015.(PDF)

Lee, C.-H., Kominos, D., Jacques, S., Margolis, B., Schlessinger, J., Shoelson, S.E. and Kuriyan, J. (1994) Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase. Structure 15: 423-438.(PDF)

Lee, C.-H., Lee, E.-C., Tai, S.-T., Kung, H.-J., Liu, Y.-C. and Hwang, J. (1993) A recombinant protein composed of Epidermal growth factor and Pseudomonas Exotoxin A with a deletion of toxin binding domain specifically kills EGF-receptor bearing cells. Protein Engineering 6: 433-440.(PDF)

Skolnik, E.Y., Batzer, A.G., Li, N., Lee, C.-H., Lowenstein, E., Mohammedi, M., Margolis, B. and Schlessinger, J. (1993) The function of GRB2 in linking the insulin receptor to Ras signaling pathways. Science 260: 1953-1955.(PDF)

Skolnik, E.Y., Lee, C.-H., Batzer, A.G., Zhou, M., Daly, R., Backer, J., White, M.F., Jr., and Schlessinger, J. (1993) The SH2/SH3 domain containing protein GRB2 implicated in RAS signaling interacts with two insulin induced substrates. EMBO J 12: 1929-1936.(PDF)

Lee, C.-H., Li, W., Nishimura, R., Zhou, M., Batzer, A.G., Myers, M.G., White, M.F., Jr., Schlessinger, J. and Skolnik, E.Y. (1993) Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells. Proc Natl Acad Sci USA 90: 11713-11717.(PDF)