Cell crawling is defined by a cycle of three basic steps: Edge protrusion (1), new adhesion formation (2), and cell body translocation (3). The dynamics of specific actin filament-based structures play roles in each one of these steps. Protrusion machinery, such as that found in the lamellipod, are responsible for pushing the plasma membrane forward. Substrate adhesion is mediated through specialized actin filament bundles that are themselves, the myosin II-based stress fibers, actin arcs. We are using superresolution imaging of live-cells to investigate the dynamics of this contractile machinery and how it contributes to cell movement.
For more information, contact Dylan Burnette.
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