Lipid droplets are organelles composed of neutral lipids surrounded by a phospholipid monolayer. They are present in most cell types, and they interact dynamically with nearly every organelle in the cell. It is likely that lipid droplets play a key role in shuttling specific classes of lipids between compartments in response to changing conditions. Nevertheless, the cell biology of these organelles is not well understood. We are using live cell imaging of fluorescently tagged proteins and lipids to study lipid droplet biogenesis and the interaction of lipid droplets with other organelles.
Figure: NRK cells stained with Nile Red, a dye that fluoresces yellow-gold in the hydrophobic environment of the lipid droplet.
For more information, contact Sarah Cohen.
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