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Eunice Kennedy Shriver National Institute of Child Health and Human Development - Section on Physical Biochemistry
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SPB publications (1993-2011)

Roberts-Pilgrim, A.M., Makareeva, E., Myles, M.H., Besch-Williford, C.L., Brodeur, A.C., Walker, A.L., Leikin, S., Franklin, C.L., and Phillips, C.L. (2011). Deficient degradation of homotrimeric type I collagen, alpha1(I)(3) glomerulopathy in oim mice. Mol Genet Metab 104, 373-82.

Makareeva, E., Aviles, N.A., and Leikin, S. (2011). Chaperoning osteogenesis: new protein-folding disease paradigms. Trends Cell Biol 21, 168-76.

Lindahl, K., Barnes, A.M., Fratzl-Zelman, N., Whyte, M.P., Hefferan, T.E., Makareeva, E., Brusel, M., Yaszemski, M.J., Rubin, C.J., Kindmark, A., Roschger, P., Klaushofer, K., McAlister, W.H., Mumm, S., Leikin, S., Kessler, E., Boskey, A.L., Ljunggren, O., and Marini, J.C. (2011). COL1 C-propeptide cleavage site mutations cause high bone mass osteogenesis imperfecta. Hum Mutat 32, 598-609.

Kornyshev, A.A., Lee, D.J., Wynveen, A., and Leikin, S. (2011). Signatures of DNA flexibility, interactions and sequence-related structural variations in classical X-ray diffraction patterns. Nucleic Acids Res 39, 7289-7299.

Cortini, R., Kornyshev, A.A., Lee, D.J., and Leikin, S. (2011). Electrostatic braiding and homologous pairing of DNA double helices. Biophys J 101, 875-84.

Tsang, K.M., Starost, M.F., Nesterova, M., Boikos, S.A., Watkins, T., Almeida, M.Q., Harran, M., Li, A., Collins, M.T., Cheadle, C., Mertz, E.L., Leikin, S., Kirschner, L.S., Robey, P., and Stratakis, C.A. (2010). Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone. Proc Natl Acad Sci U S A 107, 8683-8.

Makareeva, E., Han, S., Vera, J.C., Sackett, D.L., Holmbeck, K., Phillips, C.L., Visse, R., Nagase, H., and Leikin, S. (2010). Carcinomas contain a matrix metalloproteinase-resistant isoform of type I collagen exerting selective support to invasion. Cancer Res 70, 4366-74.

Lee, D.J., Wynveen, A., Kornyshev, A.A., and Leikin, S. (2010). Undulations enhance the effect of helical structure on DNA interactions. J Phys Chem B 114, 11668-80.

Lee, D.J., Leikin, S., and Wynveen, A. (2010). Fluctuations and interactions of semi-flexible polyelectrolytes in columnar assemblies. J Phys Condens Matter 22, 72202.

Han, S., Makareeva, E., Kuznetsova, N.V., DeRidder, A.M., Sutter, M.B., Losert, W., Phillips, C.L., Visse, R., Nagase, H., and Leikin, S. (2010). Molecular mechanism of type I collagen homotrimer resistance to mammalian collagenases. J Biol Chem 285, 22276-81.

Daley, E., Streeten, E.A., Sorkin, J.D., Kuznetsova, N., Shapses, S.A., Carleton, S.M., Shuldiner, A.R., Marini, J.C., Phillips, C.L., Goldstein, S.A., Leikin, S., and McBride, D.J., Jr. (2010). Variable bone fragility associated with an Amish COL1A2 variant and a knock-in mouse model. J Bone Miner Res 25, 247-61.

Barnes, A.M., Carter, E.M., Cabral, W.A., Weis, M., Chang, W., Makareeva, E., Leikin, S., Rotimi, C.N., Eyre, D.R., Raggio, C.L., and Marini, J.C. (2010). Lack of cyclophilin B in osteogenesis imperfecta with normal collagen folding. N Engl J Med 362, 521-8.

Panaroni, C., Gioia, R., Lupi, A., Besio, R., Goldstein, S.A., Kreider, J., Leikin, S., Vera, J.C., Mertz, E.L., Perilli, E., Baruffaldi, F., Villa, I., Farina, A., Casasco, M., Cetta, G., Rossi, A., Frattini, A., Marini, J.C., Vezzoni, P., and Forlino, A. (2009). In utero transplantation of adult bone marrow decreases perinatal lethality and rescues the bone phenotype in the knockin murine model for classical, dominant osteogenesis imperfecta. Blood 114, 459-68.

Wynveen, A., Lee, D. J., Kornyshev, A. A. and Leikin, S. (2008). Helical coherence of DNA in crystals and solution.. Nucleic Acids Res 36, 5540-51.

Pace, J. M., Wiese, M., Drenguis, A. S., Kuznetsova, N., Leikin, S., Schwarze, U., Chen, D., Mooney, S. H., Unger, S. and Byers, P. H. (2008). Defective C-propeptides of the proalpha2(I) chain of type I procollagen impede molecular assembly and result in osteogenesis imperfecta. J Biol Chem 283, 16061-7.

Makareeva, E., Mertz, E. L., Kuznetsova, N. V., Sutter, M. B., DeRidder, A. M., Cabral, W. A., Barnes, A. M., McBride, D. J., Marini, J. C. and Leikin, S. (2008). Structural heterogeneity of type I collagen triple helix and its role in osteogenesis imperfecta. J Biol Chem 283, 4787-98.

Han, S., McBride, D. J., Losert, W. and Leikin, S. (2008). Segregation of type I collagen homo- and heterotrimers in fibrils. J Mol Biol 383, 122-32.

Baldwin, G. S., Brooks, N. J., Robson, R. E., Wynveen, A., Goldar, A., Leikin, S., Seddon, J. M. and Kornyshev, A. A. (2008). DNA double helices recognize mutual sequence homology in a protein free environment. J Phys Chem B 112, 1060-4.

Mertz, E. L. and Sullivan, J. V. (2007). Solvent-resistant, inlet-gas-temperature-controlled, thermal-expansion compensated cell for light spectroscopy US Patent Application #11/826,806.

Mertz, E. L. (2007). Conditions for insensitivity of the microscopic-scale dielectric response to structural details of dipolar liquids. Phys Rev E 76, 062503.

Makareeva, E. and Leikin, S. (2007). Procollagen triple helix assembly: an unconventional chaperone-assisted folding paradigm. PLoS ONE 2, e1029.

Kornyshev, A. A., Lee, D. J., Leikin, S. and Wynveen, A. (2007). Structure and interactions of biological helices. Rev Mod Phys 79, 943-996.

Forlino, A., Kuznetsova, N. V., Marini, J. C. and Leikin, S. (2007). Selective retention and degradation of molecules with a single mutant alpha1(I) chain in the Brtl IV mouse model of OI. Matrix Biol 26, 604-14.

Cabral, W. A., Makareeva, E., Letocha, A. D., Scribanu, N., Fertala, A., Steplewski, A., Keene, D. R., Persikov, A. V., Leikin, S. and Marini, J. C. (2007). Y-position cysteine substitution in type I collagen (alpha1(I) R888C/p.R1066C) is associated with osteogenesis imperfecta/Ehlers-Danlos syndrome phenotype. Hum Mutat 28, 396-405.

Cabral, W. A., Chang, W., Barnes, A. M., Weis, M., Scott, M. A., Leikin, S., Makareeva, E., Kuznetsova, N. V., Rosenbaum, K. N., Tifft, C. J., Bulas, D. I., Kozma, C., Smith, P. A., Eyre, D. R. and Marini, J. C. (2007). Prolyl 3-hydroxylase 1 deficiency causes a recessive metabolic bone disorder resembling lethal/severe osteogenesis imperfecta. Nat Genet 39, 359-65.

Makareeva, E., Cabral, W. A., Marini, J. C. and Leikin, S. (2006). Molecular mechanism of alpha 1(I)-osteogenesis imperfecta/Ehlers-Danlos syndrome: unfolding of an N-anchor domain at the N-terminal end of the type I collagen triple helix. J Biol Chem 281, 6463-70.

Flor-Cisneros, A. and Leikin, S. (2006). Osteogenesis Imperfecta. In Clinical Studies in Medical Biochemistry (Glew, R. H. & Rosenthal, M. D., eds.), pp. 30-41. Oxford Univ. Press., Oxford.

Barnes, A. M., Chang, W., Morello, R., Cabral, W. A., Weis, M., Eyre, D. R., Leikin, S., Makareeva, E., Kuznetsova, N., Uveges, T. E., Ashok, A., Flor, A. W., Mulvihill, J. J., Wilson, P. L., Sundaram, U. T., Lee, B. and Marini, J. C. (2006). Deficiency of cartilage-associated protein in recessive lethal osteogenesis imperfecta. N Engl J Med 355, 2757-64.

Mertz, E. L. and Sullivan, J. V. (2005). Flow-through, thermal-expansion-compensated cell for light spectroscopy US Patent # 7,355,697.

Mertz, E. L. (2005). Anomalous microscopic dielectric response of dipolar solvents and water. J Phys Chem A 109, 44-56.

Kornyshev, A. A., Lee, D. J., Leikin, S., Wynveen, A. and Zimmerman, S. B. (2005). Direct observation of azimuthal correlations between DNA in hydrated aggregates. Phys Rev Lett 95, 148102.

Cabral, W. A., Makareeva, E., Colige, A., Letocha, A. D., Ty, J. M., Yeowell, H. N., Pals, G., Leikin, S. and Marini, J. C. (2005). Mutations near amino end of alpha1(I) collagen cause combined osteogenesis imperfecta/Ehlers-Danlos syndrome by interference with N-propeptide processing. J Biol Chem 280, 19259-69.

Mertz, E. L. and Leikin, S. (2004). Interactions of inorganic phosphate and sulfate anions with collagen. Biochemistry 43, 14901-12.

Kuznetsova, N. V., Forlino, A., Cabral, W. A., Marini, J. C. and Leikin, S. (2004). Structure, stability and interactions of type I collagen with GLY349-CYS substitution in alpha 1(I) chain in a murine Osteogenesis Imperfecta model. Matrix Biol 23, 101-12.

Cherstvy, A. G., Kornyshev, A. A. and Leikin, S. (2004). Torsional Deformation of Double Helix in Interaction and Aggregation of DNA. J Phys Chem B 108, 6508-6518.

Kuznetsova, N. V., McBride, D. J. and Leikin, S. (2003). Changes in thermal stability and microunfolding pattern of collagen helix resulting from the loss of alpha2(I) chain in osteogenesis imperfecta murine. J Mol Biol 331, 191-200.

Cabral, W. A., Mertts, M. V., Makareeva, E., Colige, A., Tekin, M., Pandya, A., Leikin, S. and Marini, J. C. (2003). Type I collagen triplet duplication mutation in lethal osteogenesis imperfecta shifts register of alpha chains throughout the helix and disrupts incorporation of mutant helices into fibrils and extracellular matrix. J Biol Chem 278, 10006-12.

Leikina, E., Mertts, M. V., Kuznetsova, N. and Leikin, S. (2002). Type I collagen is thermally unstable at body temperature. Proc Natl Acad Sci U S A 99, 1314-8.

Kornyshev, A. A., Leikin, S. and Malinin, S. V. (2002). Chiral electrostatic interaction and cholesteric liquid crystals of DNA. Eur Phys J E 7, 83-93.

Cherstvy, A. G., Kornyshev, A. A. and Leikin, S. (2002). Temperature-Dependent DNA Condensation Triggered by Rearrangement of Adsorbed Cations. J Phys Chem B 106, 13362-13369.

Kuznetsova, N., McBride, D. J., Jr. and Leikin, S. (2001). Osteogenesis imperfecta murine: interaction between type I collagen homotrimers. J Mol Biol 309, 807-15.

Kornyshev, A. A. and Leikin, S. (2001). Sequence recognition in the pairing of DNA duplexes. Phys Rev Lett 86, 3666-9.

Bonnet-Gonnet, C., Leikin, S., Chi, S., Rau, D. C. and Parsegian, V. A. (2001). Measurement of forces between hydroxypropylcellulose polymers: Temperature favored assembly and salt exclusion. J Phys Chem B 105, 1877-1886.

Kornyshev, A. A. and Leikin, S. (2000). Electrostatic interaction between long, rigid helical macromolecules at all interaxial angles. Phys Rev E 62, 2576-96.

Kornyshev, A. A. and Leikin, S. (2000). Twist in chiral interaction between biological helices. Phys Rev Lett 84, 2537-2540.

Mertz, E. L. and Krishtalik, L. I. (2000). Low dielectric response in enzyme active site. Proc Natl Acad Sci U S A 97, 2081-2086.

Kuznetsova, N. and Leikin, S. (1999). Does the triple helical domain of type I collagen encode molecular recognition and fiber assembly while telopeptides serve as catalytic domains? Effect of proteolytic cleavage on fibrillogenesis and on collagen-collagen interaction in fibers. J Biol Chem 274, 36083-36088.

Kornyshev, A. A. and Leikin, S. (1999). Electrostatic zipper motif for DNA aggregation. Phys Rev Lett 82, 4138-4141.

Kuznetsova, N., Chi, S. L. and Leikin, S. (1998). Sugars and polyols inhibit fibrillogenesis of type I collagen by disrupting hydrogen-bonded water bridges between the helices. Biochemistry 37, 11888-95.

Kornyshev, A. A. and Leikin, S. (1998). Electrostatic interaction between helical macromolecules in dense aggregates: an impetus for DNA poly- and meso-morphism. Proc Natl Acad Sci U S A 95, 13579-84.

Kornyshev, A. A. and Leikin, S. (1998). Symmetry laws for interaction between helical macromolecules. Biophys J 75, 2513-9.

Leikin, S., Parsegian, V. A., Yang, W. and Walrafen, G. E. (1997). Raman spectral evidence for hydration forces between collagen triple helices. Proc Natl Acad Sci U S A 94, 11312-7.

Kuznetsova, N., Rau, D. C., Parsegian, V. A. and Leikin, S. (1997). Solvent hydrogen-bond network in protein self-assembly: solvation of collagen triple helices in nonaqueous solvents. Biophys J 72, 353-62.

Kornyshev, A. A., Leikin, S. and Sutmann, G. (1997). ''Overscreening'' in a polar liquid as a result of coupling between polarization and density fluctuations. Electrochim Acta 42, 849-865.

Kornyshev, A. A. and Leikin, S. (1997). Theory of interaction between helical molecules. J Chem Phys 107, 3656-3674.

Leikin, S., Kozlov, M. M., Fuller, N. L. and Rand, R. P. (1996). Measured effects of diacylglycerol on structural and elastic properties of phospholipid membranes. Biophys J 71, 2623-32.

Leikin, S., Rau, D. C. and Parsegian, V. A. (1995). Temperature-favoured assembly of collagen is driven by hydrophilic not hydrophobic interactions. Nat Struct Biol 2, 205-10.

Kornyshev, A. A., Kossakowski, D. A. and Leikin, S. (1995). Landau Theory of a System with 2 Bilinearly Coupled Order Parameters in External-Field - Exact Mean-Field Solution, Critical Properties and Isothermal Susceptibility. Z Naturforsch 50a, 789-794.

Leikin, S., Rau, D. C. and Parsegian, V. A. (1994). Direct measurement of forces between self-assembled proteins: temperature-dependent exponential forces between collagen triple helices. Proc Natl Acad Sci U S A 91, 276-80.

Leikin, S. and Parsegian, V. A. (1994). Temperature-induced complementarity as a mechanism for biomolecular assembly. Proteins 19, 73-6.

Kozlov, M. M., Leikin, S. and Rand, R. P. (1994). Bending, hydration and interstitial energies quantitatively account for the hexagonal-lamellar-hexagonal reentrant phase transition in dioleoylphosphatidylethanolamine. Biophys J 67, 1603-11.

Leikin, S., Parsegian, V. A., Rau, D. C. and Rand, R. P. (1993). Hydration forces. Annu Rev Phys Chem 44, 369-95.

Fang, Y., Rand, R. P., Leikin, S. and Kozlov, M. M. (1993). Chain-melting reentrant transition in bimolecular layers at large separations. Phys Rev Lett 70, 3623-3626.