One goal of this Section is to understand fundamental physical mechanisms governing tissue functional properties and tissue-level physiological processes that are essential for life, or necessary to achieve a high quality of life. Examples include information transfer in the central nervous system (CNS), transport processes within the extracellular matrix (ECM), effective load bearing in cartilage, .... This entails discovering relationships between physiological function and a tissue's hierarchical structure, organization, and physical properties. We study a variety of biological model systems using quantitative approaches (e.g., biological models, biophysical methods, mathematical models, biomimetic model systems). A related tandem aim is to use non-invasive novel imaging methodologies, primarily employing Magnetic Resonance imaging (MRI), to measure and map these salient variables and parameters within tissues and organs, with the goal of using this information to improve the assessment of normal and abnormal development, disease, degeneration, trauma and aging.
NIH Record article about former mentee, Derek Jones