The Weinstein Lab is in the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), one of the institutes comprising the National Institutes of Health (NIH). The laboratory is located on the NIH main campus in Bethesda, Maryland, a few miles outside of Washington, D.C.
In the Weinstein Laboratory, we study the embryonic origins of the vertebrate vascular system, primarily using the zebrafish. Genetic and experimental analysis of the formation of this early-developing, essential organ system is difficult in most vertebrates, but the zebrafish is a model organism that offers important advantages for these studies. We make full use of these advantages in our research work, which is aimed at understanding what guides the specification, differentiation, patterning, and morphogenesis of blood vessels and lymphatic vessels during embryogenesis.
Studies of vascular development have tremendous potential medical relevance. Cardiovascular-associated mortality is the leading cause of death in the western world. Many of the developmental processes we study are important in human congenital and acquired vascular diseases, and some of the mutations we have already characterized model known human congenital disorders. There is also great interest in using anti-angiogenic therapies to combat cancer by "starving" tumors of their blood supply, or pro-angiogenic therapies to treat or prevent limb and cardiovascular ischemia. Many of the genes and proteins targeted for these therapies also play critical roles in developing vessels, and the developmental studies being carried out in our laboratory are unearthing additional potentially medically useful molecules.
Postdoctoral Position - Angiogenesis and Lymphangiogenesis
Postdoctoral Position- Bioinformatics - Computational Analysis of Vascular Development
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