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            In a related project, we are addressing the cell cycle-dependent regulation of the yeast histone genes. We have shown that they are activated by both Spt10 and SBF. Spt10 is an unusual trans-activator, in which a HAT domain, normally recruited as a co-activator to promoters through an activation domain, is attached directly to a sequence-specific DNA-binding domain. Currently, we are following chromatin structure dynamics during the cell cycle. We aim to test our model for histone gene regulation, which posits that the extent to which histone chaperones are saturated with histones is the critical signal for negative feedback control of transcription.

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