Space Details - Pfeifer Lab: Section on Genomic Imprinting

Name Pfeifer Lab: Section on Genomic Imprinting

Key sgi

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Created by Anna Schmidt

(Mar 03, 2008)

Categories dir, ged, lab

Description We are using molecular, genetic, and biochemical approaches to elucidate molecular mechanisms for genomic imprinting, a phenomenon whereby expression of certain genes is restricted to either the paternal or the maternal allele. Genomic imprinting has significant implications in developmental biology, and disruptions in the allele-specific patterns of expression are implicated in several childhood disorders. Our focus is on mouse distal chromosome 7, a region with syntony to human 11p15.5 (associated with Beckwith-Wiedemann Syndrome and with Wilms\' Tumor), and on the role of the unique H19 RNA in regulating expression of itself and its neighboring imprinted genes. A particular interest of our Unit is to use this system to understand the role of chromosome organization in gene regulation.

Administrators Amy Kolodin, Parkhurst, Amy (NIH/NICHD) [C], Pfeifer, Karl (NIH/NICHD) [E], Weinstein, Brant (NIH/NICHD) [E]

Contact

Karl E. Pfeifer, PhD

Contact

Karl E. Pfeifer, PhD

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